甲酰肽受体 1 和甲酰肽受体 2 的比较分析揭示了共享和保留的信号特征

IF 6.8 2区医学 Q1 PHARMACOLOGY & PHARMACY British Journal of Pharmacology Pub Date : 2024-09-18 DOI:10.1111/bph.17334

Denise Pajonczyk, Merle F. Sternschulte, Oliver Soehnlein, Marcel Bermudez, Carsten A. Raabe, Ursula Rescher

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引用次数: 0

摘要

模式识别受体、甲酰基肽受体、FPR1 和 FPR2 是 G 蛋白偶联受体，可识别多种不同的病原体和宿主配体。FPR1 传递促炎症信号，而 FPR2 则与促消炎结果有关。为了分析这两种非常相似的 FPRs 如何在调节炎症反应方面发挥相反的作用，尽管它们具有高度的同源性、在免疫细胞上有共同的表达谱以及有重叠的配体库，我们对这两种受体之间的信号谱是否存在差异提出了质疑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Comparative analysis of formyl peptide receptor 1 and formyl peptide receptor 2 reveals shared and preserved signalling profiles

The pattern recognition receptors, formyl peptide receptors, FPR1 and FPR2, are G protein-coupled receptors that recognize many different pathogen- and host-derived ligands. While FPR1 conveys pro-inflammatory signals, FPR2 is linked with pro-resolving outcomes. To analyse how the two very similar FPRs exert opposite effects in modulating inflammatory responses despite their high homology, a shared expression profile on immune cells and an overlapping ligand repertoire, we questioned whether the signalling profile differs between these two receptors.

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来源期刊

British Journal of Pharmacology 医学-药学

CiteScore

15.40

自引率

12.30%

发文量

270

审稿时长

2.0 months

期刊介绍： The British Journal of Pharmacology (BJP) is a biomedical science journal offering comprehensive international coverage of experimental and translational pharmacology. It publishes original research, authoritative reviews, mini reviews, systematic reviews, meta-analyses, databases, letters to the Editor, and commentaries. Review articles, databases, systematic reviews, and meta-analyses are typically commissioned, but unsolicited contributions are also considered, either as standalone papers or part of themed issues. In addition to basic science research, BJP features translational pharmacology research, including proof-of-concept and early mechanistic studies in humans. While it generally does not publish first-in-man phase I studies or phase IIb, III, or IV studies, exceptions may be made under certain circumstances, particularly if results are combined with preclinical studies.