Emmanuel Gomes Ciolac, Jana Babjakova, Raphael Martins de Abreu, Su-Jie Mao, Guoping Qian, Vanessa Teixeira do Amaral, Bartlomiej Wrzesinski, Artur Junio Togneri Ferron, Zbigniew Ossowski, Fabiane Valentini Francisqueti-Ferron, Seda Cansu Yeniğün, Bianca Fernandes, Luis Monteiro Rodrigues, Rahima Gabulova
{"title":"性别和训练特点对运动影响心血管衰老的作用:随机试验荟萃分析系统综述方案","authors":"Emmanuel Gomes Ciolac, Jana Babjakova, Raphael Martins de Abreu, Su-Jie Mao, Guoping Qian, Vanessa Teixeira do Amaral, Bartlomiej Wrzesinski, Artur Junio Togneri Ferron, Zbigniew Ossowski, Fabiane Valentini Francisqueti-Ferron, Seda Cansu Yeniğün, Bianca Fernandes, Luis Monteiro Rodrigues, Rahima Gabulova","doi":"10.1186/s13643-024-02644-8","DOIUrl":null,"url":null,"abstract":"Cardiovascular diseases remain a leading global cause of mortality worldwide especially in older adults. Although it is known that regular exercise reduces cardiovascular diseases incidence, its effects on specific cardiovascular aging parameters considering the influence of sex and different exercise designs are still not fully understood. Therefore, this systematic review and meta-analysis aims to evaluate the effects of different physical exercise protocols on age-related cardiovascular outcomes in older adults. This systematic review and meta-analysis will be reported in agreement with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Articles will be eligible if they are randomized controlled trials with a primary objective of evaluating the chronic effects of exercise interventions on cardiovascular aging parameters. Search strategy will be performed from the inception to September 30th, 2023, in the following electronic databases: MEDLINE (Ovid), SCOPUS (Elsevier), Embase, Sport Discus (EBSCO), Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science Core Collection (Clarivate Analytics). Data will be extracted and managed through Research Electronic Data Capture (REDCap) software. The Tool for the assEssment of Study qualiTy and reporting in EXercise (TESTEX) will be used to assess the methodological quality of included studies. Additionally, the quality of the findings will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) profiler. Meta-analysis based on the random-effects model will be performed (if deemed suitable, considering the methodological and clinical heterogeneity of the studies) to estimate the effects of exercise training on cardiovascular aging variables (i.e., cardiac output; arterial stiffness; stroke volume; endothelial function; and carotid intima-media thickness). Heterogeneity will be assessed with the I2 statistics, while the publication bias will be assessed based on Egger’s test. To the best of our knowledge, this will be the first systematic review and meta-analysis to investigate the impact of sex and training protocols on the cardiovascular aging parameters. Moreover, the findings of this systematic review and meta-analysis will provide evidence for health professionals in the management of elderly patients in order to optimize the exercise prescription to face the cardiovascular alterations related to the aging process, considering the effects of different protocols according to sex. 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引用次数: 0
摘要
心血管疾病仍然是全球尤其是老年人死亡的主要原因。尽管众所周知,定期锻炼可降低心血管疾病的发病率,但考虑到性别和不同锻炼设计的影响,锻炼对特定心血管衰老参数的影响仍未得到充分了解。因此,本系统综述和荟萃分析旨在评估不同体育锻炼方案对老年人与年龄相关的心血管结果的影响。本系统综述和荟萃分析将按照《系统综述和荟萃分析首选报告项目》(PRISMA)声明进行报告。只要是以评估运动干预对心血管衰老参数的慢性影响为主要目标的随机对照试验,均符合条件。检索策略将从开始至 2023 年 9 月 30 日在以下电子数据库中进行:MEDLINE (Ovid), SCOPUS (Elsevier), Embase, Sport Discus (EBSCO), Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science Core Collection (Clarivate Analytics)。数据将通过研究电子数据采集(REDCap)软件进行提取和管理。运动研究质量和报告评估工具(TESTEX)将用于评估纳入研究的方法学质量。此外,还将使用建议评估、发展和评价分级(GRADE)剖析器评估研究结果的质量。考虑到研究的方法学和临床异质性,如果认为合适,将基于随机效应模型进行 Meta 分析,以估计运动训练对心血管衰老变量(即心输出量、动脉僵化、每搏量、内皮功能和颈动脉内膜中层厚度)的影响。异质性将通过 I2 统计量进行评估,而发表偏倚将通过 Egger 检验进行评估。据我们所知,这将是首个研究性别和训练方案对心血管衰老参数影响的系统综述和荟萃分析。此外,本系统综述和荟萃分析的结果将为医护人员管理老年患者提供证据,以便优化运动处方,应对与衰老过程有关的心血管变化,同时考虑到不同方案对不同性别的影响。PERCOMO CRD42023441015 .
Role of sex and training characteristics on exercise effects on cardiovascular aging: protocol for a systematic review with meta-analysis of randomized trials
Cardiovascular diseases remain a leading global cause of mortality worldwide especially in older adults. Although it is known that regular exercise reduces cardiovascular diseases incidence, its effects on specific cardiovascular aging parameters considering the influence of sex and different exercise designs are still not fully understood. Therefore, this systematic review and meta-analysis aims to evaluate the effects of different physical exercise protocols on age-related cardiovascular outcomes in older adults. This systematic review and meta-analysis will be reported in agreement with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Articles will be eligible if they are randomized controlled trials with a primary objective of evaluating the chronic effects of exercise interventions on cardiovascular aging parameters. Search strategy will be performed from the inception to September 30th, 2023, in the following electronic databases: MEDLINE (Ovid), SCOPUS (Elsevier), Embase, Sport Discus (EBSCO), Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science Core Collection (Clarivate Analytics). Data will be extracted and managed through Research Electronic Data Capture (REDCap) software. The Tool for the assEssment of Study qualiTy and reporting in EXercise (TESTEX) will be used to assess the methodological quality of included studies. Additionally, the quality of the findings will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) profiler. Meta-analysis based on the random-effects model will be performed (if deemed suitable, considering the methodological and clinical heterogeneity of the studies) to estimate the effects of exercise training on cardiovascular aging variables (i.e., cardiac output; arterial stiffness; stroke volume; endothelial function; and carotid intima-media thickness). Heterogeneity will be assessed with the I2 statistics, while the publication bias will be assessed based on Egger’s test. To the best of our knowledge, this will be the first systematic review and meta-analysis to investigate the impact of sex and training protocols on the cardiovascular aging parameters. Moreover, the findings of this systematic review and meta-analysis will provide evidence for health professionals in the management of elderly patients in order to optimize the exercise prescription to face the cardiovascular alterations related to the aging process, considering the effects of different protocols according to sex. PROSPERO CRD42023441015 .
期刊介绍:
Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal publishes high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modelling. At this time Systematic Reviews does not accept reviews of in vitro studies. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.