{"title":"孕期血清胆固醇水平升高是产后高胆固醇血症的预测因素:前瞻性队列研究","authors":"Yandi Zhu, Haiyan Zhu, Qinyu Dang, Qian Yang, Xiaoyan Zhao, Yadi Zhang, Xiaxia Cai, Zhuo Hu, Yuchen Wei, Zhaoyang Chen, Huanling Yu","doi":"10.1002/ijgo.15922","DOIUrl":null,"url":null,"abstract":"ObjectiveTo identify the associations between gestational cholesterol levels and the risk of postpartum hypercholesterolemia, and to establish trimester‐specific reference values.MethodsSerum lipids at gestational weeks 6–8, 16, 24, and 36, and 42 days postpartum were derived from 905 pregnant women of a prospective cohort. The major outcome was postpartum hypercholesterolemia. Logistic regression and restricted cubic splines were conducted to estimate the associations between cholesterol levels at specific gestational ages and postpartum hypercholesterolemia. Associations of the trend of changes in cholesterol levels during pregnancy with postpartum hypercholesterolemia were evaluated by linear mixed‐effect model and linear or logistic regression. Reference values were computed by the receiver operating characteristic curves.ResultsSerum concentrations of total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C), and the ratios of TC/HDL‐C and LDL‐C/HDL‐C all increased during pregnancy and decreased at 42 days postpartum. The elevated levels of TC and LDL‐C, decreased levels of HDL‐C in pregnancy, and their rapid change rates were positively associated with higher risks of postpartum hypercholesterolemia. The established reference values from the first to the third trimester were below 5.47, 6.35, and 7.22 mmol/L for TC; below 2.83, 3.82, and 4.21 mmol/L for LDL‐C; and more than 1.50, 1.55, and 1.50 mmol/L for HDL‐C, respectively.ConclusionMaternal cholesterol levels and their trend of change during pregnancy were predictors of postpartum hypercholesterolemia. Trimester‐specific reference values were established in a Chinese population.","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Elevated serum cholesterol levels during pregnancy as predictors for postpartum hypercholesterolemia: A prospective cohort study\",\"authors\":\"Yandi Zhu, Haiyan Zhu, Qinyu Dang, Qian Yang, Xiaoyan Zhao, Yadi Zhang, Xiaxia Cai, Zhuo Hu, Yuchen Wei, Zhaoyang Chen, Huanling Yu\",\"doi\":\"10.1002/ijgo.15922\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"ObjectiveTo identify the associations between gestational cholesterol levels and the risk of postpartum hypercholesterolemia, and to establish trimester‐specific reference values.MethodsSerum lipids at gestational weeks 6–8, 16, 24, and 36, and 42 days postpartum were derived from 905 pregnant women of a prospective cohort. The major outcome was postpartum hypercholesterolemia. Logistic regression and restricted cubic splines were conducted to estimate the associations between cholesterol levels at specific gestational ages and postpartum hypercholesterolemia. Associations of the trend of changes in cholesterol levels during pregnancy with postpartum hypercholesterolemia were evaluated by linear mixed‐effect model and linear or logistic regression. Reference values were computed by the receiver operating characteristic curves.ResultsSerum concentrations of total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C), and the ratios of TC/HDL‐C and LDL‐C/HDL‐C all increased during pregnancy and decreased at 42 days postpartum. The elevated levels of TC and LDL‐C, decreased levels of HDL‐C in pregnancy, and their rapid change rates were positively associated with higher risks of postpartum hypercholesterolemia. The established reference values from the first to the third trimester were below 5.47, 6.35, and 7.22 mmol/L for TC; below 2.83, 3.82, and 4.21 mmol/L for LDL‐C; and more than 1.50, 1.55, and 1.50 mmol/L for HDL‐C, respectively.ConclusionMaternal cholesterol levels and their trend of change during pregnancy were predictors of postpartum hypercholesterolemia. Trimester‐specific reference values were established in a Chinese population.\",\"PeriodicalId\":14164,\"journal\":{\"name\":\"International Journal of Gynecology & Obstetrics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Gynecology & Obstetrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/ijgo.15922\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Gynecology & Obstetrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ijgo.15922","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Elevated serum cholesterol levels during pregnancy as predictors for postpartum hypercholesterolemia: A prospective cohort study
ObjectiveTo identify the associations between gestational cholesterol levels and the risk of postpartum hypercholesterolemia, and to establish trimester‐specific reference values.MethodsSerum lipids at gestational weeks 6–8, 16, 24, and 36, and 42 days postpartum were derived from 905 pregnant women of a prospective cohort. The major outcome was postpartum hypercholesterolemia. Logistic regression and restricted cubic splines were conducted to estimate the associations between cholesterol levels at specific gestational ages and postpartum hypercholesterolemia. Associations of the trend of changes in cholesterol levels during pregnancy with postpartum hypercholesterolemia were evaluated by linear mixed‐effect model and linear or logistic regression. Reference values were computed by the receiver operating characteristic curves.ResultsSerum concentrations of total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C), and the ratios of TC/HDL‐C and LDL‐C/HDL‐C all increased during pregnancy and decreased at 42 days postpartum. The elevated levels of TC and LDL‐C, decreased levels of HDL‐C in pregnancy, and their rapid change rates were positively associated with higher risks of postpartum hypercholesterolemia. The established reference values from the first to the third trimester were below 5.47, 6.35, and 7.22 mmol/L for TC; below 2.83, 3.82, and 4.21 mmol/L for LDL‐C; and more than 1.50, 1.55, and 1.50 mmol/L for HDL‐C, respectively.ConclusionMaternal cholesterol levels and their trend of change during pregnancy were predictors of postpartum hypercholesterolemia. Trimester‐specific reference values were established in a Chinese population.
期刊介绍:
The International Journal of Gynecology & Obstetrics publishes articles on all aspects of basic and clinical research in the fields of obstetrics and gynecology and related subjects, with emphasis on matters of worldwide interest.