{"title":"利用分子建模探索分枝杆菌氧化磷酸化抑制剂的化学空间","authors":"Islam K. Matar, Zhongmin Dong, Chérif F. Matta","doi":"10.1002/cmdc.202400303","DOIUrl":null,"url":null,"abstract":"Intracellular pathogens are exceedingly clinically challenging, including pathogenic mycobacteria. Many global efforts are currently in action to battle these notorious disease agents. This review provides an overview of mycobacteria, along with their associated diseases, pathogenesis, and exploitable respiratory vulnerabilities to supplement contemporary antimycobacterial discovery.","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"50 1","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the Chemical Space of Mycobacterial Oxidative Phosphorylation Inhibitors Using Molecular Modeling\",\"authors\":\"Islam K. Matar, Zhongmin Dong, Chérif F. Matta\",\"doi\":\"10.1002/cmdc.202400303\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Intracellular pathogens are exceedingly clinically challenging, including pathogenic mycobacteria. Many global efforts are currently in action to battle these notorious disease agents. This review provides an overview of mycobacteria, along with their associated diseases, pathogenesis, and exploitable respiratory vulnerabilities to supplement contemporary antimycobacterial discovery.\",\"PeriodicalId\":147,\"journal\":{\"name\":\"ChemMedChem\",\"volume\":\"50 1\",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2024-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemMedChem\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/cmdc.202400303\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemMedChem","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/cmdc.202400303","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Exploring the Chemical Space of Mycobacterial Oxidative Phosphorylation Inhibitors Using Molecular Modeling
Intracellular pathogens are exceedingly clinically challenging, including pathogenic mycobacteria. Many global efforts are currently in action to battle these notorious disease agents. This review provides an overview of mycobacteria, along with their associated diseases, pathogenesis, and exploitable respiratory vulnerabilities to supplement contemporary antimycobacterial discovery.
期刊介绍：
Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs.
Contents
ChemMedChem publishes an attractive mixture of:
Full Papers and Communications
Reviews and Minireviews
Patent Reviews
Highlights and Concepts
Book and Multimedia Reviews.
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