战争还是和平病毒与转移

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-09-17 DOI:10.1016/j.bbcan.2024.189179
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引用次数: 0

摘要

转移是指恶性细胞从原发肿瘤扩散到继发部位,给癌症治疗带来灾难性负担,也是癌症患者死亡的主要原因。转移是癌症进展的主要方面之一,可能受到病毒感染的强烈影响。事实上,病毒一直是现代癌症研究的核心,与大量癌症病例有关。病毒编码元素参与调节重要通路或特定靶点,而这些通路或靶点与癌症转移的不同阶段有牵连。考虑到新病毒的不断涌现及其对癌症进展的贡献,病毒与癌症之间的战争似乎是无止境的。在此,我们旨在回顾癌症转移所涉及的关键机制和途径,以及病毒机制的影响和病毒为自身利益操纵这些途径所采用的各种途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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War or peace: Viruses and metastasis

Metastasis, the dissemination of malignant cells from a primary tumor to secondary sites, poses a catastrophic burden to cancer treatment and is the predominant cause of mortality in cancer patients. Metastasis as one of the main aspects of cancer progression could be strongly under the influence of viral infections. In fact, viruses have been central to modern cancer research and are associated with a great number of cancer cases. Viral-encoded elements are involved in modulating essential pathways or specific targets that are implicated in different stages of metastasis. Considering the continuous emergence of new viruses and the establishment of their contribution to cancer progression, the warfare between viruses and cancer appears to be endless. Here we aimed to review the critical mechanism and pathways involved in cancer metastasis and the influence of viral machinery and various routes that viruses adopt to manipulate those pathways for their benefit.

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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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