{"title":"通过信息学增强预测骨骼肌组织的破坏强度","authors":"","doi":"10.1016/j.engfracmech.2024.110476","DOIUrl":null,"url":null,"abstract":"<div><p>Skeletal muscles are susceptible to injury during daily activities and competitive sports. Reliable prediction of tissue failure strength is a major challenge due to the large uncertainty in the mechanical behavior of skeletal muscle tissue. The present study reveals a strong correlation between histological characteristics and skeletal muscle failure strength by means of mechanical and histological experiments. We propose a data-driven hybrid modeling approach that enables an effective integration of data science and informatics tools to capture tissue failure strength. Uncertainty in the tissue failure strength is propagated into the posterior information of reduced model parameters via the Bayesian inference framework and parameter space compression. A histological enhancement to the softening hyperelasticity model is made by linking a quantified tissue-scale histological characteristic and stiff model parameters using artificial neural networks. The model is applied to skeletal muscle tissue from different species and sites to assess its predictive capabilities for physiological differences. The results show that the approach can achieve reliable predictions of skeletal muscle tissue failure strength. The proposed approach can be extended to different scales to enrich the understanding of structure–property linkages for biomaterials.</p></div>","PeriodicalId":11576,"journal":{"name":"Engineering Fracture Mechanics","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Informatics-enhanced prediction of failure strength in skeletal muscle tissue\",\"authors\":\"\",\"doi\":\"10.1016/j.engfracmech.2024.110476\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Skeletal muscles are susceptible to injury during daily activities and competitive sports. Reliable prediction of tissue failure strength is a major challenge due to the large uncertainty in the mechanical behavior of skeletal muscle tissue. The present study reveals a strong correlation between histological characteristics and skeletal muscle failure strength by means of mechanical and histological experiments. We propose a data-driven hybrid modeling approach that enables an effective integration of data science and informatics tools to capture tissue failure strength. Uncertainty in the tissue failure strength is propagated into the posterior information of reduced model parameters via the Bayesian inference framework and parameter space compression. A histological enhancement to the softening hyperelasticity model is made by linking a quantified tissue-scale histological characteristic and stiff model parameters using artificial neural networks. The model is applied to skeletal muscle tissue from different species and sites to assess its predictive capabilities for physiological differences. The results show that the approach can achieve reliable predictions of skeletal muscle tissue failure strength. The proposed approach can be extended to different scales to enrich the understanding of structure–property linkages for biomaterials.</p></div>\",\"PeriodicalId\":11576,\"journal\":{\"name\":\"Engineering Fracture Mechanics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-09-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Engineering Fracture Mechanics\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0013794424006398\",\"RegionNum\":2,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MECHANICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Engineering Fracture Mechanics","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0013794424006398","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MECHANICS","Score":null,"Total":0}
Informatics-enhanced prediction of failure strength in skeletal muscle tissue
Skeletal muscles are susceptible to injury during daily activities and competitive sports. Reliable prediction of tissue failure strength is a major challenge due to the large uncertainty in the mechanical behavior of skeletal muscle tissue. The present study reveals a strong correlation between histological characteristics and skeletal muscle failure strength by means of mechanical and histological experiments. We propose a data-driven hybrid modeling approach that enables an effective integration of data science and informatics tools to capture tissue failure strength. Uncertainty in the tissue failure strength is propagated into the posterior information of reduced model parameters via the Bayesian inference framework and parameter space compression. A histological enhancement to the softening hyperelasticity model is made by linking a quantified tissue-scale histological characteristic and stiff model parameters using artificial neural networks. The model is applied to skeletal muscle tissue from different species and sites to assess its predictive capabilities for physiological differences. The results show that the approach can achieve reliable predictions of skeletal muscle tissue failure strength. The proposed approach can be extended to different scales to enrich the understanding of structure–property linkages for biomaterials.
期刊介绍:
EFM covers a broad range of topics in fracture mechanics to be of interest and use to both researchers and practitioners. Contributions are welcome which address the fracture behavior of conventional engineering material systems as well as newly emerging material systems. Contributions on developments in the areas of mechanics and materials science strongly related to fracture mechanics are also welcome. Papers on fatigue are welcome if they treat the fatigue process using the methods of fracture mechanics.