液相色谱-串联质谱法检测临床样本中甲状腺激素和甲状腺球蛋白的最新进展:综述

IF 2.8 3区 工程技术 Q2 CHEMISTRY, ANALYTICAL Journal of separation science Pub Date : 2024-09-18 DOI:10.1002/jssc.202400466
Yuting Jin, Taiyu Zhai, Ying Wang, Jiuyan Li, Tingting Wang, Jing Huang
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引用次数: 0

摘要

甲状腺激素(THs),包括三碘甲状腺原氨酸(T3)、甲状腺素(T4)及其代谢产物,对于调节发育、生长和能量代谢至关重要。甲状腺滤泡细胞产生的甲状腺球蛋白(Tg)是合成 TH 的重要底物。THs与Tg的结合是一种广泛应用于甲状腺功能评估的血清学实验室检测方法。早期检测和及时干预对于预防和控制甲状腺疾病意义重大。近年来,液相色谱-串联质谱(LC-MS/MS)以其高灵敏度和高特异性成为临床上精确检测小分子分析物和类固醇激素的有力工具。最近,LC-MS/MS 被越来越多地用于检测 THs 和 Tg,但其在临床实践中的应用仍处于早期阶段。本文回顾了 2004-2023 年间发表的利用 LC-MS/MS 对临床样本中的甲状腺代谢进行评估的最新进展,并特别关注了该技术在量化甲状腺疾病相关分子方面的应用。
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Recent advances in liquid chromatography-tandem mass spectrometry for the detection of thyroid hormones and thyroglobulin in clinical samples: A review

Thyroid hormones (THs), including triiodothyronine (T3), thyroxine (T4), and their metabolites, are essential for regulating development, growth, and energy metabolism. Thyroglobulin (Tg) produced by thyroid follicular cells acts as an essential substrate for TH synthesis. The combination of THs with Tg is a widely used serological laboratory test for thyroid function assessment. Early detection and timely intervention are significant for preventing and managing thyroid disease. In recent years, liquid chromatography-tandem mass spectrometry (LC-MS/MS) has emerged as a powerful tool for the precise detection of small molecular analytes and steroid hormones in clinical practice as a result of its high sensitivity and specificity. While LC-MS/MS has been increasingly used for detecting THs and Tg recently, its application in clinical practice is still in its early stages. Recent advances in the assessment of thyroid metabolism using LC-MS/MS in clinical samples published during 2004–2023 were reviewed, with a special focus on the use of this technique for quantifying molecules involved in thyroid diseases.

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来源期刊
Journal of separation science
Journal of separation science 化学-分析化学
CiteScore
6.30
自引率
16.10%
发文量
408
审稿时长
1.8 months
期刊介绍: The Journal of Separation Science (JSS) is the most comprehensive source in separation science, since it covers all areas of chromatographic and electrophoretic separation methods in theory and practice, both in the analytical and in the preparative mode, solid phase extraction, sample preparation, and related techniques. Manuscripts on methodological or instrumental developments, including detection aspects, in particular mass spectrometry, as well as on innovative applications will also be published. Manuscripts on hyphenation, automation, and miniaturization are particularly welcome. Pre- and post-separation facets of a total analysis may be covered as well as the underlying logic of the development or application of a method.
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