铱催化邻羟基苯基烯酮还原合成苯丙酮及其在 3-甲基铬酮合成中的应用。

IF 2.8 3区化学 Q1 CHEMISTRY, ORGANIC Organic & Biomolecular Chemistry Pub Date : 2024-09-16 Epub Date: 2024-09-10 DOI:10.1039/d4ob01359j

Zhi Tu , Jie-Ping Wan , Li Wei , Yunyun Liu

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引用次数: 0

摘要

一种以硅烷为还原剂，通过铱催化还原邻羟基苯丙酮的方法已经实现。研究发现，还原反应是通过苯环上的羟基辅助进行的。此外，邻羟基苯丙酮产品还被用于直接加入 N,N-二甲基甲酰胺二甲基缩醛（DMF-DMA），在不使用任何催化剂的情况下轻松合成 3-甲基色酮。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Iridium-catalyzed reduction of o-hydroxyl phenyl enaminones for the synthesis of propiophenones and their application in 3-methyl chromone synthesis†

A method of reducing o-hydroxyphenyl enaminones with silane as the reductant to provide o-hydroxyl propiophenones has been achieved with iridium catalysis. The reduction reactions were found to proceed via the assistance of the hydroxyl group in the phenyl ring. In addition, the o-hydroxyl propiophenone products were used for the easy synthesis of 3-methyl chromones by directly incorporating N,N-dimethyl formamide dimethyl acetal (DMF-DMA) without using any catalyst.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.