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引用次数: 0
摘要
胰岛素自动给药系统(AID)将连续血糖监测(CGM)系统与胰岛素泵(连续皮下胰岛素输注)的胰岛素给药算法连接起来,从而改善了胰岛素治疗糖尿病患者的血糖水平,提高了他们的生活质量。本综述总结了胰岛素泵和 CGM 设备之间的连接所带来的益处。它详细介绍了实现连接的技术要求和进步,并强调了此类系统的临床和用户益处。本文将重点介绍在 1 型糖尿病(T1D)患者中使用 AID 系统的临床试验和实际效果;同时还将讨论在 2 型糖尿病(T2D)和其他糖尿病亚型患者中使用 AID 系统的效果。我们还将详细介绍当前连接胰岛素泵和 CGM 设备的技术方法的局限性。在认识到这些障碍的同时,我们还讨论了未来的机遇。
Automating insulin delivery through pump and continuous glucose monitoring connectivity: Maximizing opportunities to improve outcomes.
The development of automated insulin delivery (AID) systems, which connect continuous glucose monitoring (CGM) systems with algorithmic insulin delivery from an insulin pump (continuous subcutaneous insulin infusion, [CSII]), has led to improved glycaemia and quality of life benefits in those with insulin-treated diabetes. This review summarizes the benefits gained by the connectivity between insulin pumps and CGM devices. It details the technical requirements and advances that have enabled this, and highlights the clinical and user benefits of such systems. Clinical trials and real-world outcomes from the use of AID systems in people with type 1 diabetes (T1D) will be the focus of this article; outcomes in people with type 2 diabetes (T2D) and other diabetes subtypes will also be discussed. We also detail the limitations of current technological approaches for connectivity between insulin pumps and CGM devices. While recognizing the barriers, we discuss opportunities for the future.
期刊介绍:
Diabetes, Obesity and Metabolism is primarily a journal of clinical and experimental pharmacology and therapeutics covering the interrelated areas of diabetes, obesity and metabolism. The journal prioritises high-quality original research that reports on the effects of new or existing therapies, including dietary, exercise and lifestyle (non-pharmacological) interventions, in any aspect of metabolic and endocrine disease, either in humans or animal and cellular systems. ‘Metabolism’ may relate to lipids, bone and drug metabolism, or broader aspects of endocrine dysfunction. Preclinical pharmacology, pharmacokinetic studies, meta-analyses and those addressing drug safety and tolerability are also highly suitable for publication in this journal. Original research may be published as a main paper or as a research letter.