Caleb J C McKinney, William Bigelow, Preethi G Venkat, Neeral L Shah
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引用次数: 0
摘要
免疫抑制患者可能出现乙型肝炎病毒（HBV）再活化。具体来说，嵌合抗原受体 T 细胞（CAR T 细胞）治疗后的 HBV 再激活是一种已知的并发症，但很少有病例报告和具体的治疗指南。我们的患者在接受 CAR T 细胞治疗 27 个月后，即使服用了 23 个月的恩替卡韦预防药物，仍出现了 HBV 再激活。这一独特的病例凸显了进一步研究 CAR T 细胞疗法后 HBV 再激活风险以及在 CAR T 细胞疗法期间和之后采取适当的 HBV 预防措施的必要性。
Post-Chimeric Antigen Receptor T-Cell Therapy Hepatitis B Virus Reactivation After 23 Months of Entecavir Prophylaxis.
Hepatitis B virus (HBV) reactivation can occur in immunosuppressed patients. Specifically, HBV reactivation after chimeric antigen receptor T-cell (CAR T-cell) therapy is a known complication with few case reports and specific treatment guidelines. Our patient experienced HBV reactivation 27 months after CAR T-cell therapy even with 23 months of entecavir prophylaxis. This unique case highlights the need for further investigation into the risk of HBV reactivation after CAR T-cell therapy and the proper HBV prophylaxis during and after CAR T-cell therapy.
期刊介绍：
ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.
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