评估有肺部受累和无肺部受累的 COVID-19 患者中 ACE2 G8790A 和 AT2R A1675G 基因多态性之间的关系。

IF 0.4 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Asian Biomedicine Pub Date : 2024-09-20 eCollection Date: 2024-08-01 DOI:10.2478/abm-2024-0022

Raziye Akcilar, Fatma Emel Kocak, Fatih Kar, Ozben Ozden Isiklar, Sahinde Atlanoglu, Ozlem Genc, Fatima Yaman

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引用次数: 0

摘要

背景SARS-CoV-2病毒可导致严重急性呼吸系统综合征。冠状病毒病 2019（COVID-19）感染的严重程度由多种因素决定，包括遗传因素：我们的目标是研究有肺部受累和无肺部受累的COVID-19患者中ACE2 G8790A（rs2285666）和AT2R A1675G（rs14035430）基因多态性之间的联系：根据临床症状将160名COVID-19患者分为两组：无肺部受累者（对照组）和肺部受累者（感染组）。采用 PCR-RFLP 方法分析 ACE2 G8790A 和 AT2R A1675G 基因多态性：结果：ACE2 G8790A的GG基因型、G等位基因和AT2R A1675G的GG基因型在对照组中明显较高，对COVID-19有保护作用，并能减少肺部受累的发生（OR = 0.29，95% CI = 0.10-0.84；OR = 0.40，95% CI = 0.22-0.72；OR = 0.33，95% CI = 0.14-0.78）。此外，我们发现AA基因型、ACE2 G8790A的A等位基因和AT2R A1675G的AG基因型会增加感染组患COVID-19的风险（OR = 3.50，95% CI = 1.18-10.3；OR = 2.49，95% CI = 1.39-4.48；OR = 3.08，95% CI = 1.28-7.38）：这些结果表明，在土耳其人群中，COVID-19 肺部受累的更高频率与 AA 基因型、ACE2 G8790A 的 A 等位基因和 AT2R A1675G 的 AG 基因型有关。

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Evaluation of the relationship between ACE2 G8790A and AT2R A1675G gene polymorphisms in COVID-19 patients with and without lung involvement.

Background: The SARS-CoV-2 virus produces severe acute respiratory syndrome. The severity of coronavirus disease 2019 (COVID-19) infection is determined by a number of factors, including inherited ones.

Objectives: Our goal is to investigate the link between ACE2 G8790A (rs2285666) and AT2R A1675G (rs14035430) gene polymorphisms in COVID-19 patients with and without lung involvement.

Methods: A total of 160 COVID-19 patients were divided into 2 groups based on their clinical symptoms: those without lung involvement (control group) and those with lung involvement (infected group). The ACE2 G8790A and AT2R A1675G gene polymorphisms were analyzed using the PCR-RFLP methods.

Results: The GG genotype, G allele of ACE2 G8790A, and GG genotype of AT2R A1675G were significantly higher in the control group and had a protective effect against COVID-19 as well as decreased the development of lung involvement (OR = 0.29, 95% CI = 0.10-0.84; OR = 0.40, 95% CI = 0.22-0.72; and OR = 0.33, 95% CI = 0.14-0.78, respectively). Moreover, we found that the AA genotype, A allele of ACE2 G8790A, and AG genotype of AT2R A1675G increased the risk of COVID-19 in the infected group (OR = 3.50, 95% CI = 1.18-10.3; OR = 2.49, 95% CI = 1.39-4.48; and OR = 3.08, 95% CI = 1.28-7.38, respectively).

Conclusions: These results revealed that a greater frequency of COVID-19 lung involvement in the Turkish population was connected with the AA genotype, the A allele of ACE2 G8790A, and the AG genotype of AT2R A1675G.

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来源期刊

Asian Biomedicine 医学-医学：研究与实验

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Asian Biomedicine: Research, Reviews and News (ISSN 1905-7415 print; 1875-855X online) is published in one volume (of 6 bimonthly issues) a year since 2007. [...]Asian Biomedicine is an international, general medical and biomedical journal that aims to publish original peer-reviewed contributions dealing with various topics in the biomedical and health sciences from basic experimental to clinical aspects. The work and authorship must be strongly affiliated with a country in Asia, or with specific importance and relevance to the Asian region. The Journal will publish reviews, original experimental studies, observational studies, technical and clinical (case) reports, practice guidelines, historical perspectives of Asian biomedicine, clinicopathological conferences, and commentaries Asian biomedicine is intended for a broad and international audience, primarily those in the health professions including researchers, physician practitioners, basic medical scientists, dentists, educators, administrators, those in the assistive professions, such as nurses, and the many types of allied health professionals in research and health care delivery systems including those in training.