AB094.体重指数与胶质瘤患者分级和存活率的关系

IF 2.1 4区 医学 Q3 ONCOLOGY Chinese clinical oncology Pub Date : 2024-08-01 DOI:10.21037/cco-24-ab094
Dian Caturini Sulistyoningrum, Alfian Rismawan, Rusdy Ghazali Malueka, Ery Kus Dwianingsih
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引用次数: 0

摘要

背景:胶质瘤是第二种最常见的脑肿瘤,占所有脑肿瘤病例的 24%。体重指数(BMI)对胶质瘤的影响尚不明确,关于较高的体重指数与罹患某些脑肿瘤的风险之间的关系,研究结果相互矛盾。胶质母细胞瘤是胶质瘤的一种侵袭性恶性肿瘤,治疗方案有限,预后较差,一些研究显示,胶质母细胞瘤与体重指数有关,表明体重指数较高的人患胶质母细胞瘤的风险可能较高。然而,我们仍需全面了解这种关系的内在机制及其程度。本研究旨在探讨 BMI 与胶质瘤患者分级和存活率之间的相关性:方法:研究人员对印度尼西亚日惹萨吉托博士综合医院经组织学确诊的117名胶质瘤患者进行了回顾性横断面分析。临床数据来自医疗记录。体重指数通过测量体重(公斤)除以身高平方(平方米)计算得出。统计分析的重点是评估体重指数、肿瘤分级和患者存活率之间的关系:在117名胶质瘤患者中,胶质母细胞瘤是最常见的肿瘤类型(48.7%;n=57/117),其次是弥漫性星形细胞瘤(22%;n=26/117)。其余病例包括无弹性上皮瘤、无弹性少突胶质细胞瘤和朝粒细胞星形细胞瘤。大多数患者为男性(61%),平均年龄为 47.5 岁,年龄介于 20 岁至 79 岁之间。平均体重指数(BMI)为 23.5 kg/m2,表明亚洲人处于超重状态,超过一半的患者处于超重或肥胖状态(54%,n=63/117)。此外,有 10 名患者体重不足。体重指数越高,分级和存活率越高。然而,BMI与肿瘤分级(P=0.23)或生存率(P=0.26)之间未发现明显关联:尽管在胶质瘤患者的体重指数、肿瘤分级和生存期之间没有发现明显的关联,但仍有必要进行进一步的研究。应进一步调查患者中超重和肥胖的高发率,以便为患者管理和护理提供有价值的见解。
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AB094. Association of body mass index with grading and survival of glioma patients.

Background: Glioma is the second most common type of brain tumor, representing 24% of all brain tumor cases. The role of body mass index (BMI) on glioma remains unclear, with conflicting findings regarding the association between higher BMI and the risk of developing certain brain tumors. Glioblastoma, an aggressive and malignant form of glioma with limited treatment options and a poor prognosis, has been linked to BMI in some studies, suggesting that individuals with higher BMIs may have an elevated risk of glioblastoma development. However, a comprehensive understanding of the mechanisms underlying this relationship and its extent is still needed. The study aimed to investigate the correlation between BMI and the grading and survival of glioma patients.

Methods: A retrospective cross-sectional analysis was conducted on 117 histologically confirmed glioma patients at Dr. Sardjito General Hospital in Yogyakarta, Indonesia. Clinical data were collected from medical records. BMI was calculated by measuring weights (kg) and dividing it by squared heights (m2). The statistical analysis focused on assessing the association between BMI, tumor grade, and patient survival.

Results: Among 117 glioma patients, glioblastoma was the most prevalent tumor type (48.7%; n=57/117), followed by diffuse astrocytoma (22%; n=26/117). The remaining cases included anaplastic ependymoma, anaplastic oligodendroglioma, and pilocytic astrocytoma. Most patients were male (61%), with an average age of 47.5 years, age ranges between 20 and 79 years. The majority had grade IV of World Health Organization (WHO) classification (58%, n=68/117), while only two patients were classified as grade I. The average BMI was 23.5 kg/m2, indicating overweight status for the Asian population, with more than half of the patients being overweight or obese (54%, n=63/117). Additionally, ten patients were underweight. There was a trend of higher BMI being associated with higher grading and survival. However, no significant association between BMI and tumor grade (P=0.23) or survival (P=0.26) was found.

Conclusions: Although no significant associations were found between BMI, tumor grade, and survival in glioma patients, further studies are warranted. The high prevalence of overweight and obesity among patients should be further investigated to provide valuable insights for patient management and care.

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期刊介绍: The Chinese Clinical Oncology (Print ISSN 2304-3865; Online ISSN 2304-3873; Chin Clin Oncol; CCO) publishes articles that describe new findings in the field of oncology, and provides current and practical information on diagnosis, prevention and clinical investigations of cancer. Specific areas of interest include, but are not limited to: multimodality therapy, biomarkers, imaging, tumor biology, pathology, chemoprevention, and technical advances related to cancer. The aim of the Journal is to provide a forum for the dissemination of original research articles as well as review articles in all areas related to cancer. It is an international, peer-reviewed journal with a focus on cutting-edge findings in this rapidly changing field. To that end, Chin Clin Oncol is dedicated to translating the latest research developments into best multimodality practice. The journal features a distinguished editorial board, which brings together a team of highly experienced specialists in cancer treatment and research. The diverse experience of the board members allows our editorial panel to lend their expertise to a broad spectrum of cancer subjects.
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