了解癌症中的沃伯格效应

IF 7.8 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Cold Spring Harbor perspectives in medicine Pub Date : 2024-09-16 DOI:10.1101/cshperspect.a041532
Zhaoqi Li, Muhammad Bin Munim, Daniel A Sharygin, Brooke J Bevis, Matthew G Vander Heiden
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引用次数: 0

摘要

包括癌细胞在内的快速增殖细胞会调整新陈代谢,以满足细胞生长和分裂对能量和生物合成的更高需求。许多快速增殖的细胞表现出更多的葡萄糖消耗和发酵,而不受氧气供应的影响,这种表型被称为有氧糖酵解或癌症中的沃伯格效应。对于细胞为何进行有氧糖酵解以及有氧糖酵解如何支持细胞增殖,人们提出了几种解释,但没有一种解释能完全解释观察到有氧糖酵解的所有条件和数据。不过,有令人信服的证据表明,沃伯格效应对许多癌症的增殖非常重要,抑制葡萄糖摄取或发酵都会影响肿瘤生长。在此,我们将讨论与有氧糖酵解相关的新陈代谢的已知情况,以及支持有氧糖酵解在癌症和其他情况下可能具有重要作用的各种解释的证据。
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Understanding the Warburg Effect in Cancer.

Rapidly proliferating cells, including cancer cells, adapt metabolism to meet the increased energetic and biosynthetic demands of cell growth and division. Many rapidly proliferating cells exhibit increased glucose consumption and fermentation regardless of oxygen availability, a phenotype termed aerobic glycolysis or the Warburg effect in cancer. Several explanations for why cells engage in aerobic glycolysis and how it supports proliferation have been proposed, but none can fully explain all conditions and data where aerobic glycolysis is observed. Nevertheless, there is convincing evidence that the Warburg effect is important for the proliferation of many cancers, and that inhibiting either glucose uptake or fermentation can impair tumor growth. Here, we discuss what is known about metabolism associated with aerobic glycolysis and the evidence supporting various explanations for why aerobic glycolysis may be important in cancer and other contexts.

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来源期刊
Cold Spring Harbor perspectives in medicine
Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
14.30
自引率
1.90%
发文量
44
审稿时长
4-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.
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