意大利 IBD 患者疾病控制不理想的原因：IBD-PODCAST 研究。

IF 4 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Digestive and Liver Disease Pub Date : 2025-01-01 DOI:10.1016/j.dld.2024.08.040

Emma Calabrese , Sara Onali , Angela Variola , Davide Giuseppe Ribaldone , Edoardo Vincenzo Savarino , Anna Viola , Simone Saibeni , Francesco Simone Conforti , Anna Testa , Giovanni Latella , Ambrogio Orlando , Mariabeatrice Principi , Antonino Carlo Privitera , Maria Guerra , Linda Ceccarelli , Giammarco Mocci , Davide Boy , Maria Adelaide Piccarozzi , Giuliana Gualberti , Francesca Marando , Ferdinando D'Amico

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引用次数: 0

摘要

背景和目的：根据 STRIDE-II 标准，IBD 的次优疾病控制（SDC）及其诱因尚不明确。IBD-PODCAST 是一项非干预性的国际多中心真实世界研究，旨在评估这一问题：方法：本文提供的数据来自意大利 IBD 队列（N=220）。年龄≥19岁、确诊IBD≥1年的参与者被连续纳入研究。医生和患者在过去 12 个月内进行了回顾性病历审查和横断面评估。采用改编的 STRIDE-II 标准评估 SDC 或最佳疾病控制情况：结果：在指标日期，116 名 CD 患者中有 53.4% 患有 SDC，104 名 UC 患者中有 49.0% 患有 SDC，主要归因于炎症性肠病短问卷评分：这项研究表明，在相当一部分 IBD 意大利患者中存在 SDC。这些结果表明，有必要对 CD 和 UC 患者采取更积极的管理策略。

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Suboptimal disease control and contributing factors in Italian IBD patients: The IBD-PODCAST Study

Background and Aim

Suboptimal disease control (SDC) and its contributing factors in IBD according to STRIDE-II criteria is unclear. IBD-PODCAST was a non-interventional, international, multicenter real-world study to assess this.

Methods

Data from the Italian IBD cohort (N=220) are presented here. Participants aged ≥19 with confirmed IBD diagnosis of ≥1 year were consecutively enrolled. A retrospective chart review and cross-sectional assessment by physicians and patients within the past 12 months were performed. SDC or optimal disease control was assessed using adapted STRIDE-II criteria.

Results

At the index date, 53.4 % of 116 CD patients and 49.0 % of 104 UC patients had SDC, mainly attributed to a Short Inflammatory Bowel Disease Questionnaire score <50, failure to achieve endoscopic remission, and the presence of active extra-intestinal manifestations in both diseases. Disease monitoring with imaging and/or endoscopy during the previous year was conducted in ∼50 % of patients, with endoscopy performed in ∼40 %. Potential therapeutic adjustments were reported for half of the patients.

Conclusions

This study highlights SDC in a significant portion of IBD Italian patients. These results emphasize the need for more proactive management strategies in both CD and UC patients.

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来源期刊

Digestive and Liver Disease 医学-胃肠肝病学

CiteScore

6.10

自引率

2.20%

发文量

632

审稿时长

19 days

期刊介绍： Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.