Urs Bannert, Ulrike Siewert-Markus, Johanna Klinger-König, Hans J Grabe, Sylvia Stracke, Marcus Dörr, Henry Völzke, Marcello R P Markus, Philipp Töpfer, Till Ittermann
{"title":"重度抑郁症的复发与女性肥胖相关特征的差异有关，但与男性无关。","authors":"Urs Bannert, Ulrike Siewert-Markus, Johanna Klinger-König, Hans J Grabe, Sylvia Stracke, Marcus Dörr, Henry Völzke, Marcello R P Markus, Philipp Töpfer, Till Ittermann","doi":"10.1192/j.eurpsy.2024.1764","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Obesity-related cardiometabolic comorbidity is common in major depressive disorder (MDD). However, sex differences and MDD recurrence may modify the MDD-obesity-link.</p><p><strong>Methods: </strong>Sex-specific associations of MDD recurrence (single [MDD<sub>S</sub>] or recurrent episodes [MDD<sub>R</sub>]) and obesity-related traits were analyzed in 4.100 adults (51.6% women) from a cross-sectional population-based cohort in Germany (SHIP-Trend-0). DSM-IV-based lifetime MDD diagnoses and MDD recurrence status were obtained through diagnostic interviews. Obesity-related outcomes included anthropometrics (weight, body mass index, waist- and hip-circumference, waist-to-hip ratio, waist-to-height ratio), bioelectrical impedance analysis of body fat mass and fat-free mass, and subcutaneous (SAT) and visceral adipose tissue (VAT) from abdominal magnetic resonance imaging. Sex-stratified linear regression models predicting obesity-related traits from MDD recurrence status were adjusted for age, education, and current depressive symptoms.</p><p><strong>Results: </strong>790 participants (19.3%) fulfilled lifetime MDD criteria (23.8% women vs. 14.5% men, p<0.001). In women, MDD<sub>S</sub> was inversely associated with anthropometric indicators of general and central obesity, while MDD<sub>R</sub> was positively associated with all obesity-related traits, except waist-to-hip ratio and fat-free mass. In women, MDD<sub>R</sub> versus MDD<sub>S</sub> was associated with higher levels of obesity across all outcomes except fat-free mass. In men, MDD was positively associated with SAT regardless of MDD recurrence. Additionally, lifetime MDD was positively associated with VAT in men. Results remained significant in sensitivity analyses after exclusion of participants with current use of antidepressants.</p><p><strong>Conclusions: </strong>The MDD-obesity association is modified by MDD recurrence and sex independent of current depressive symptoms. Accounting for sex and MDD recurrence may identify individuals with MDD at increased cardiometabolic risk.</p>","PeriodicalId":12155,"journal":{"name":"European Psychiatry","volume":"67 1","pages":"e55"},"PeriodicalIF":7.2000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457113/pdf/","citationCount":"0","resultStr":"{\"title\":\"Major depression recurrence is associated with differences in obesity-related traits in women, but not in men.\",\"authors\":\"Urs Bannert, Ulrike Siewert-Markus, Johanna Klinger-König, Hans J Grabe, Sylvia Stracke, Marcus Dörr, Henry Völzke, Marcello R P Markus, Philipp Töpfer, Till Ittermann\",\"doi\":\"10.1192/j.eurpsy.2024.1764\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Obesity-related cardiometabolic comorbidity is common in major depressive disorder (MDD). However, sex differences and MDD recurrence may modify the MDD-obesity-link.</p><p><strong>Methods: </strong>Sex-specific associations of MDD recurrence (single [MDD<sub>S</sub>] or recurrent episodes [MDD<sub>R</sub>]) and obesity-related traits were analyzed in 4.100 adults (51.6% women) from a cross-sectional population-based cohort in Germany (SHIP-Trend-0). DSM-IV-based lifetime MDD diagnoses and MDD recurrence status were obtained through diagnostic interviews. Obesity-related outcomes included anthropometrics (weight, body mass index, waist- and hip-circumference, waist-to-hip ratio, waist-to-height ratio), bioelectrical impedance analysis of body fat mass and fat-free mass, and subcutaneous (SAT) and visceral adipose tissue (VAT) from abdominal magnetic resonance imaging. Sex-stratified linear regression models predicting obesity-related traits from MDD recurrence status were adjusted for age, education, and current depressive symptoms.</p><p><strong>Results: </strong>790 participants (19.3%) fulfilled lifetime MDD criteria (23.8% women vs. 14.5% men, p<0.001). In women, MDD<sub>S</sub> was inversely associated with anthropometric indicators of general and central obesity, while MDD<sub>R</sub> was positively associated with all obesity-related traits, except waist-to-hip ratio and fat-free mass. In women, MDD<sub>R</sub> versus MDD<sub>S</sub> was associated with higher levels of obesity across all outcomes except fat-free mass. In men, MDD was positively associated with SAT regardless of MDD recurrence. Additionally, lifetime MDD was positively associated with VAT in men. Results remained significant in sensitivity analyses after exclusion of participants with current use of antidepressants.</p><p><strong>Conclusions: </strong>The MDD-obesity association is modified by MDD recurrence and sex independent of current depressive symptoms. Accounting for sex and MDD recurrence may identify individuals with MDD at increased cardiometabolic risk.</p>\",\"PeriodicalId\":12155,\"journal\":{\"name\":\"European Psychiatry\",\"volume\":\"67 1\",\"pages\":\"e55\"},\"PeriodicalIF\":7.2000,\"publicationDate\":\"2024-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457113/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1192/j.eurpsy.2024.1764\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1192/j.eurpsy.2024.1764","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Major depression recurrence is associated with differences in obesity-related traits in women, but not in men.
Background: Obesity-related cardiometabolic comorbidity is common in major depressive disorder (MDD). However, sex differences and MDD recurrence may modify the MDD-obesity-link.
Methods: Sex-specific associations of MDD recurrence (single [MDDS] or recurrent episodes [MDDR]) and obesity-related traits were analyzed in 4.100 adults (51.6% women) from a cross-sectional population-based cohort in Germany (SHIP-Trend-0). DSM-IV-based lifetime MDD diagnoses and MDD recurrence status were obtained through diagnostic interviews. Obesity-related outcomes included anthropometrics (weight, body mass index, waist- and hip-circumference, waist-to-hip ratio, waist-to-height ratio), bioelectrical impedance analysis of body fat mass and fat-free mass, and subcutaneous (SAT) and visceral adipose tissue (VAT) from abdominal magnetic resonance imaging. Sex-stratified linear regression models predicting obesity-related traits from MDD recurrence status were adjusted for age, education, and current depressive symptoms.
Results: 790 participants (19.3%) fulfilled lifetime MDD criteria (23.8% women vs. 14.5% men, p<0.001). In women, MDDS was inversely associated with anthropometric indicators of general and central obesity, while MDDR was positively associated with all obesity-related traits, except waist-to-hip ratio and fat-free mass. In women, MDDR versus MDDS was associated with higher levels of obesity across all outcomes except fat-free mass. In men, MDD was positively associated with SAT regardless of MDD recurrence. Additionally, lifetime MDD was positively associated with VAT in men. Results remained significant in sensitivity analyses after exclusion of participants with current use of antidepressants.
Conclusions: The MDD-obesity association is modified by MDD recurrence and sex independent of current depressive symptoms. Accounting for sex and MDD recurrence may identify individuals with MDD at increased cardiometabolic risk.
期刊介绍：
European Psychiatry, the official journal of the European Psychiatric Association, is dedicated to sharing cutting-edge research, policy updates, and fostering dialogue among clinicians, researchers, and patient advocates in the fields of psychiatry, mental health, behavioral science, and neuroscience. This peer-reviewed, Open Access journal strives to publish the latest advancements across various mental health issues, including diagnostic and treatment breakthroughs, as well as advancements in understanding the biological foundations of mental, behavioral, and cognitive functions in both clinical and general population studies.
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