现在没有了格列齐芬,该如何治疗头癣呢?

IF 4.2 2区 医学 Q1 INFECTIOUS DISEASES Expert Review of Anti-infective Therapy Pub Date : 2024-09-19 DOI:10.1080/14787210.2024.2405936
Alexandro Bonifaz, Paola Lumbán-Ramírez, Roxana S García-Sotelo, Helena Vidaurri de la Cruz, Mirna Toledo-Bahena, Adriana Valencia-Herrera
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引用次数: 0

摘要

简介格列齐芬于 1939 年被发现,1959 年开始在市场上销售,是第一种有效治疗皮肤癣菌病(尤其是头癣)的口服抗真菌药物。虽然由于其疗程长且依赖角化生成,最终被唑类抗真菌药所取代,但格列卫在治疗头癣,尤其是由犬小孢子菌引起的头癣方面的有效性和安全性仍然值得注意。然而,由于病例减少和商业上的不可得性,现在需要替代疗法:讨论了以下有关其他治疗方法的主题:(I)特比萘芬、伊曲康唑和氟康唑等替代抗真菌剂在治疗头癣中的疗效。(II) 局部疗法的使用和作用。(专家意见:讨论了口服特比萘芬替代格列齐芬治疗头癣的作用,以及为什么口服特比萘芬是老年患者的首选药物。还分析了小孢子菌属所面临的挑战以及氟康唑在儿童患者中的应用。会议还强调了支持使用局部治疗作为头癣的辅助治疗方法。
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Now that griseofulvin is not available, what to do with tinea capitis treatments?

Introduction: Griseofulvin, discovered in 1939 and commercially available since 1959, was the first oral antifungal agent effective against dermatophytosis, particularly tinea capitis. Although it was eventually superseded by azole antifungals due to its long treatment duration and reliance on keratopoiesis, griseofulvin remains notable for its effectiveness and safety in treating tinea capitis, especially when caused by Microsporum canis. However, due to a decline in cases and commercial unavailability, alternative treatments are now required.

Areas covered: The following topics regarding to other treatments were discussed: (I) The efficacy of alternative antifungal agents such as terbinafine, itraconazole, and fluconazole, in the treatment of tinea capitis. (II) The use and role of topical therapies. (III) Experience in the management of tinea capitis.

Expert opinion: The usefulness of oral terbinafine as a replacement for griseofulvin in the treatment of tinea capitis and why it is the preferred drug in elderly patients was discussed. Challenges with Microsporum spp. and the use of fluconazole in pediatric patients were also analyzed. Support for the use of topical treatment as an adjunctive treatment for tinea capitis was highlighted.

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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
66
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anti-Infective Therapy (ISSN 1478-7210) provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.
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