{"title":"结核病还是非结核病?一例分枝杆菌皮肤感染。","authors":"Merve Mert Vahabi, Aylin Bostancı, Selin Ece Taşbakan, Işıl Karaarslan, Cengiz Çavuşoğlu, Meltem Taşbakan","doi":"10.4103/ijmy.ijmy_211_23","DOIUrl":null,"url":null,"abstract":"<p><p>Bacteria other than Mycobacterium tuberculosis and Mycobacterium leprae are known as nontuberculous mycobacteria (NTM), and the frequency of clinically symptomatic forms is increasing day by day. Mycobacterium fortuitum, a rapidly reproducing NTM, causes various clinical signs such as skin soft-tissue infection, surgical site infection, and disseminated infection in immunosuppressed patients. Although progress can be made in terms of diagnosis when growth is detected in culture, it is quite difficult to distinguish between infection and contamination. There is no place for antituberculosis treatment in the treatment of M. fortuitum. Antibiotics such as quinolones, trimethoprim-sulfamethoxazole, linezolid, doxycycline, clarithromycin, azithromycin, imipenem, tigecycline, linezolid, and amikacin are recommended at least in dual combination therapy. In this case presentation, the diagnosis and treatment of a 2-year skin soft-tissue infection with M. fortuitum growth in culture will be discussed.</p>","PeriodicalId":14133,"journal":{"name":"International Journal of Mycobacteriology","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tuberculosis or Nontuberculosis? A Case of Mycobacterial Skin Infection.\",\"authors\":\"Merve Mert Vahabi, Aylin Bostancı, Selin Ece Taşbakan, Işıl Karaarslan, Cengiz Çavuşoğlu, Meltem Taşbakan\",\"doi\":\"10.4103/ijmy.ijmy_211_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Bacteria other than Mycobacterium tuberculosis and Mycobacterium leprae are known as nontuberculous mycobacteria (NTM), and the frequency of clinically symptomatic forms is increasing day by day. Mycobacterium fortuitum, a rapidly reproducing NTM, causes various clinical signs such as skin soft-tissue infection, surgical site infection, and disseminated infection in immunosuppressed patients. Although progress can be made in terms of diagnosis when growth is detected in culture, it is quite difficult to distinguish between infection and contamination. There is no place for antituberculosis treatment in the treatment of M. fortuitum. Antibiotics such as quinolones, trimethoprim-sulfamethoxazole, linezolid, doxycycline, clarithromycin, azithromycin, imipenem, tigecycline, linezolid, and amikacin are recommended at least in dual combination therapy. In this case presentation, the diagnosis and treatment of a 2-year skin soft-tissue infection with M. fortuitum growth in culture will be discussed.</p>\",\"PeriodicalId\":14133,\"journal\":{\"name\":\"International Journal of Mycobacteriology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Mycobacteriology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ijmy.ijmy_211_23\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/9/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Mycobacteriology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijmy.ijmy_211_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/14 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
摘要
结核分枝杆菌和麻风分枝杆菌以外的细菌被称为非结核分枝杆菌(NTM),有临床症状的非结核分枝杆菌出现的频率与日俱增。快速繁殖的非结核分枝杆菌会引起各种临床症状,如皮肤软组织感染、手术部位感染以及免疫抑制患者的播散性感染。虽然在培养中发现生长时,诊断方面会有所进展,但要区分感染和污染却相当困难。抗结核治疗在治疗 M. fortuitum 时没有用武之地。建议至少使用喹诺酮类、三甲双氨-磺胺甲噁唑、利奈唑胺、多西环素、克拉霉素、阿奇霉素、亚胺培南、替加环素、利奈唑胺和阿米卡星等抗生素进行双重联合治疗。在本病例报告中,将讨论对培养液中生长有 M. fortuitum 的两年期皮肤软组织感染的诊断和治疗。
Tuberculosis or Nontuberculosis? A Case of Mycobacterial Skin Infection.
Bacteria other than Mycobacterium tuberculosis and Mycobacterium leprae are known as nontuberculous mycobacteria (NTM), and the frequency of clinically symptomatic forms is increasing day by day. Mycobacterium fortuitum, a rapidly reproducing NTM, causes various clinical signs such as skin soft-tissue infection, surgical site infection, and disseminated infection in immunosuppressed patients. Although progress can be made in terms of diagnosis when growth is detected in culture, it is quite difficult to distinguish between infection and contamination. There is no place for antituberculosis treatment in the treatment of M. fortuitum. Antibiotics such as quinolones, trimethoprim-sulfamethoxazole, linezolid, doxycycline, clarithromycin, azithromycin, imipenem, tigecycline, linezolid, and amikacin are recommended at least in dual combination therapy. In this case presentation, the diagnosis and treatment of a 2-year skin soft-tissue infection with M. fortuitum growth in culture will be discussed.