Alma Lingenberg, François R Herrmann, Stéphane Armand, Julie Péron, Frédéric Assal, Gilles Allali
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Univariate and multiple linear regression models examined the association between memory performance and clinical-biological characteristics.</p><p><strong>Results: </strong>Sixty-two non-amnestic patients (mean age 77.0±7.0 years, 38.7% female) and thirty-eight amnestic patients (mean age 77.0±5.9 years, 36.8% female) presented similar levels of AD biomarkers and clinical-radiological profiles. Global cognition and education levels were lower in the amnestic iNPH group. We found no association between AD biomarkers and memory performances (total tau: β= -4.50; 95% CI [-11.96;2.96]; p = 0.236; amyloid-β (1-42): β= 8.60, 95% CI [-6.30;23.50]; p = 0.240). At baseline, amnestic iNPH patients performed worse on executive functions, attention, and gait speed but improved similarly to the non-amnestic iNPH patients after the tap test.</p><p><strong>Conclusions: </strong>In our clinical sample of iNPH patients, we confirm the lack of specificity of the amnestic profile for predicting AD pathology. 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引用次数: 0
摘要
背景:特发性正常压力脑积水(iNPH特发性正常压力脑积水(iNPH)可表现为发作性失忆综合征和阿尔茨海默病(AD)病理生物标志物:目的:研究失忆综合征与 iNPH 脑脊液(CSF)AD 生物标志物之间的关系,以及失忆综合征 iNPH 患者的脑脊液点滴试验反应:我们使用自由和诱导选择性记忆测试将 iNPH 患者分为失忆症和非失忆症患者。我们比较了他们的临床、生物学和放射学特征,并考察了 CSF tap 测试后步态时空参数和神经心理学表现的可逆性。单变量和多元线性回归模型检验了记忆表现与临床生物特征之间的关联:62名非失忆症患者(平均年龄为77.0±7.0岁,38.7%为女性)和38名失忆症患者(平均年龄为77.0±5.9岁,36.8%为女性)的AD生物标志物水平和临床放射学特征相似。失忆的 iNPH 组患者的总体认知能力和教育水平较低。我们发现,AD 生物标志物与记忆能力之间没有关联(总 tau:β= -4.50;95% CI [-11.96;2.96];p = 0.236;淀粉样蛋白-β(1-42):β= 8.60;95% CI [-11.96;2.96];p = 0.236):β=8.60,95% CI [-6.30;23.50];p = 0.240)。基线时,失忆症 iNPH 患者在执行功能、注意力和步速方面的表现较差,但在拍击测试后,他们的表现与非失忆症 iNPH 患者相似:在我们的 iNPH 患者临床样本中,我们证实了失忆特征在预测注意力缺失症病理方面缺乏特异性。临床医生不应阻止失忆症 iNPH 患者接受 CSF 提取的侵入性程序。
Forget About Memory: Disentangling the Amnestic Syndrome in Idiopathic Normal Pressure Hydrocephalus.
Background: Idiopathic normal pressure hydrocephalus (iNPH) can present with both episodic amnestic syndrome and biomarkers of Alzheimer's disease (AD) pathology.
Objective: To examine the associations between amnestic syndrome and cerebrospinal fluid (CSF) AD biomarkers in iNPH and the CSF tap test response in iNPH patients with amnestic syndrome.
Methods: We used the Free and Cued Selective Reminding Test to divide iNPH into amnestic and non-amnestic patients. We compared their clinical, biological, and radiological characteristics and examined the reversibility of gait spatiotemporal parameters and neuropsychological performances after a CSF tap test. Univariate and multiple linear regression models examined the association between memory performance and clinical-biological characteristics.
Results: Sixty-two non-amnestic patients (mean age 77.0±7.0 years, 38.7% female) and thirty-eight amnestic patients (mean age 77.0±5.9 years, 36.8% female) presented similar levels of AD biomarkers and clinical-radiological profiles. Global cognition and education levels were lower in the amnestic iNPH group. We found no association between AD biomarkers and memory performances (total tau: β= -4.50; 95% CI [-11.96;2.96]; p = 0.236; amyloid-β (1-42): β= 8.60, 95% CI [-6.30;23.50]; p = 0.240). At baseline, amnestic iNPH patients performed worse on executive functions, attention, and gait speed but improved similarly to the non-amnestic iNPH patients after the tap test.
Conclusions: In our clinical sample of iNPH patients, we confirm the lack of specificity of the amnestic profile for predicting AD pathology. Clinicians should not preclude amnestic iNPH patients from undergoing an invasive procedure of CSF derivation.
期刊介绍:
The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.