{"title":"生长阶段的精神压力频率对氧化应激、器官和骨骼发育的影响","authors":"Sangun Lee, Maho Tairabune, Yuka Nakamura, Atsunori Itagaki, Issei Sugimoto, Takumi Saito, Yoshihiko Shibukawa, Atsuko Satoh","doi":"10.11005/jbm.2024.31.3.196","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study aimed to examine the effects of psychogenic stress (PS) frequency on oxidative stress and organ development during growth and to gain fundamental insights into developmental processes during this period.</p><p><strong>Methods: </strong>Four-week-old male Wistar rats were randomly assigned to a control and three PS groups according to PS frequencies. PS was induced using restraint and water immersion techniques once daily for 3 hr at a time for a period of 4 weeks.</p><p><strong>Results: </strong>Oxidative stress increased with increasing PS frequency. The weights of organs other than the adrenal glands significantly decreased with increasing PS frequency, indicating growth suppression. Furthermore, bone morphology, weight, and length significantly decreased with increasing PS frequency.</p><p><strong>Conclusions: </strong>High-frequency PS exposure during developmental growth significantly negatively affects oxidative stress and organ and bone development. In particular, increased oxidative stress due to excessive PS has detrimental effects on organ and bone growth.</p>","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 3","pages":"196-208"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416881/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of Psychogenic Stress Frequency during the Growth Stage on Oxidative Stress, Organ and Bone Development.\",\"authors\":\"Sangun Lee, Maho Tairabune, Yuka Nakamura, Atsunori Itagaki, Issei Sugimoto, Takumi Saito, Yoshihiko Shibukawa, Atsuko Satoh\",\"doi\":\"10.11005/jbm.2024.31.3.196\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This study aimed to examine the effects of psychogenic stress (PS) frequency on oxidative stress and organ development during growth and to gain fundamental insights into developmental processes during this period.</p><p><strong>Methods: </strong>Four-week-old male Wistar rats were randomly assigned to a control and three PS groups according to PS frequencies. PS was induced using restraint and water immersion techniques once daily for 3 hr at a time for a period of 4 weeks.</p><p><strong>Results: </strong>Oxidative stress increased with increasing PS frequency. The weights of organs other than the adrenal glands significantly decreased with increasing PS frequency, indicating growth suppression. Furthermore, bone morphology, weight, and length significantly decreased with increasing PS frequency.</p><p><strong>Conclusions: </strong>High-frequency PS exposure during developmental growth significantly negatively affects oxidative stress and organ and bone development. In particular, increased oxidative stress due to excessive PS has detrimental effects on organ and bone growth.</p>\",\"PeriodicalId\":15070,\"journal\":{\"name\":\"Journal of Bone Metabolism\",\"volume\":\"31 3\",\"pages\":\"196-208\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416881/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Bone Metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.11005/jbm.2024.31.3.196\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/31 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Bone Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11005/jbm.2024.31.3.196","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/31 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Effects of Psychogenic Stress Frequency during the Growth Stage on Oxidative Stress, Organ and Bone Development.
Background: This study aimed to examine the effects of psychogenic stress (PS) frequency on oxidative stress and organ development during growth and to gain fundamental insights into developmental processes during this period.
Methods: Four-week-old male Wistar rats were randomly assigned to a control and three PS groups according to PS frequencies. PS was induced using restraint and water immersion techniques once daily for 3 hr at a time for a period of 4 weeks.
Results: Oxidative stress increased with increasing PS frequency. The weights of organs other than the adrenal glands significantly decreased with increasing PS frequency, indicating growth suppression. Furthermore, bone morphology, weight, and length significantly decreased with increasing PS frequency.
Conclusions: High-frequency PS exposure during developmental growth significantly negatively affects oxidative stress and organ and bone development. In particular, increased oxidative stress due to excessive PS has detrimental effects on organ and bone growth.
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