学龄儿童低密度脂蛋白胆固醇水平和无创血管健康评估:静冈县小笠地区研究》。

IF 3 2区 医学 Q2 PERIPHERAL VASCULAR DISEASE Journal of atherosclerosis and thrombosis Pub Date : 2024-09-19 DOI:10.5551/jat.64795
Nanaho Hasegawa, Satoru Iwashima, Yuri Furusawa, Akinari Hayakawa, Junichiro Katuki, Satoshi Hayano, Keigo Seki, Soichiro Yata, Kenichi Kinjo, Shinichiro Sano
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引用次数: 0

摘要

目的:本研究评估了静冈县小笠地区学龄儿童的低密度脂蛋白胆固醇(LDL-C)水平,并评估了非侵入性血管检测(即血流介导扩张(FMD)和血管内中膜厚度(IMT))在家族性高胆固醇血症(FH)儿科患者中的实用性:我们分析了为预防生活方式相关疾病而接受筛查的 8568 名学生的血脂检测结果,以及在 Chutoen 综合医疗中心就诊的 78 名胆固醇水平超过 220 mg/dL 的 15 岁以下儿童的血脂检测结果。我们检查了学龄筛查中低密度脂蛋白胆固醇的分布情况,并对符合《2022 年儿科 FH 指南》标准的学生进行了 FMD 和 IMT 评估:在接受筛查的学生中,有 186 人(2.2%)的低密度脂蛋白胆固醇水平超过 140 mg/dL,其中包括 123 名四年级学生(2.8%)和 63 名初中一年级学生(1.5%)。所有学生的平均低密度脂蛋白胆固醇水平为 90.0 毫克/分升(标准差:21.3 毫克/分升),第 95 百分位数约为 125.0 毫克/分升。在到医院就诊的 78 名儿童中,有 65 名符合 FH 诊断标准。在年龄≥10 岁的儿童中,确定和可能的 FH 组与可能的 FH 组之间未观察到明显的 IMT 差异;但是,这些组之间的 FMD 百分比存在显著差异(9.9% [8.1%-11.9%] vs. 14.2% [11.6%-16.3%],P=0.003):我们的研究结果突显了 FH 筛查中低密度脂蛋白胆固醇的分布情况,并表明≥ 10 岁的儿童 FH 患者的 FMD 可能会降低。这些结果强调了在学龄儿童中启动药物干预以维持最佳低密度脂蛋白胆固醇水平对终生心血管健康的重要性。
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Assessment of Low-density Lipoprotein Cholesterol Levels and Non-invasive Vascular Health in School-aged Children: A Study in Ogasa District, Shizuoka Prefecture.

Aim: The present study assessed low-density lipoprotein cholesterol (LDL-C) levels in school-aged children from the Ogasa District of Shizuoka Prefecture and evaluated the utility of non-invasive vascular tests, namely flow-mediated dilation (FMD) and intima-media thickness (IMT), in pediatric patients with familial hypercholesterolemia (FH).

Method: We analyzed the lipid test results of 8,568 students screened for prevention of lifestyle-related diseases and 78 children under 15 years old with cholesterol levels exceeding 220 mg/dL who visited Chutoen General Medical Center. We examined the LDL-C distribution from school-age screenings and conducted FMD and IMT assessments on those meeting the 2022 Pediatric FH Guidelines criteria.

Results: Among the screened students, 186 (2.2%) exhibited LDL-C levels above 140 mg/dL, including 123 fourth-graders (2.8%) and 63 first-year junior high students (1.5%). The mean LDL-C level across all students was 90.0 mg/dL (standard deviation: 21.3 mg/dL), with the 95th percentile at approximately 125.0 mg/dL. Of the 78 children who visited the hospital, 65 met the FH diagnostic criteria. In children ≥ 10 years old, no significant IMT differences were observed between the Definitive and Probable FH groups and the Possible FH group; however, a significant difference in the FMD percentage was noted between these groups (9.9% [8.1%-11.9%] vs. 14.2% [11.6%-16.3%], P=0.003).

Conclusions: Our findings highlight the LDL-C distribution in FH screening and suggest a potential reduction in FMD in pediatric FH patients ≥ 10 years old. These results emphasize the importance of initiating pharmacological interventions in school-aged children to maintain optimal LDL-C levels for lifelong cardiovascular health.

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来源期刊
CiteScore
6.60
自引率
15.90%
发文量
271
审稿时长
1 months
期刊介绍: JAT publishes articles focused on all aspects of research on atherosclerosis, vascular biology, thrombosis, lipid and metabolism.
期刊最新文献
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