Xavier Attendu, Paul R Bloemen, Niels H Kind, Dirk J Faber, Daniel M de Bruin, Caroline Boudoux, Ton G van Leeuwen
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Multimodal imaging combining optical coherence tomography (OCT) with complementary optical imaging techniques may provide enhanced diagnostic capabilities by simultaneously assessing tissue morphology and biochemical content.</p><p><strong>Aim: </strong>We aim to develop a tethered capsule endoscope (TCE) that can accommodate a variety of point-scanning techniques in addition to OCT without requiring design iterations on the optical or mechanical design.</p><p><strong>Approach: </strong>We propose a TCE utilizing exclusively reflective optics to focus and steer light from and to a double-clad fiber. Specifically, we use an ellipsoidal mirror to achieve finite conjugation between the fiber tip and the imaging plane.</p><p><strong>Results: </strong>We demonstrate a functional all-reflective TCE. We first detail the design, fabrication, and assembly steps required to obtain such a device. We then characterize its performance and demonstrate combined OCT at 1300 nm and visible spectroscopic imaging in the 500- to 700-nm range. Finally, we discuss the advantages and limitations of the proposed design.</p><p><strong>Conclusions: </strong>An all-reflective TCE is feasible and allows for achromatic high-quality imaging. 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引用次数: 0
摘要
意义重大:食管癌在西方国家的发病率越来越高。早期发现对有效治疗至关重要。将光学相干断层扫描(OCT)与辅助光学成像技术相结合的多模态成像可同时评估组织形态和生化成分,从而提高诊断能力。目的:我们旨在开发一种系留胶囊内窥镜(TCE),除 OCT 外,该内窥镜还可容纳各种点扫描技术,而无需对光学或机械设计进行迭代:方法:我们提出的 TCE 完全采用反射光学技术,将光线从双包层光纤聚焦并转向双包层光纤。具体来说,我们使用一个椭圆镜来实现光纤尖端和成像平面之间的有限共轭:我们展示了一种功能性全反射 TCE。我们首先详细介绍了获得这种设备所需的设计、制造和组装步骤。然后,我们对其性能进行了表征,并演示了 1300 纳米波长的 OCT 和 500 至 700 纳米波长范围内的可见光谱成像。最后,我们讨论了拟议设计的优势和局限性:结论:全反射 TCE 是可行的,可以实现消色差高质量成像。这种设备可用作测试各种模式组合的平台,以确定最佳候选模式,而无需反复设计。
All-reflective tethered capsule endoscope for multimodal optical coherence tomography in the esophagus.
Significance: Esophageal cancer is becoming increasingly prevalent in Western countries. Early detection is crucial for effective treatment. Multimodal imaging combining optical coherence tomography (OCT) with complementary optical imaging techniques may provide enhanced diagnostic capabilities by simultaneously assessing tissue morphology and biochemical content.
Aim: We aim to develop a tethered capsule endoscope (TCE) that can accommodate a variety of point-scanning techniques in addition to OCT without requiring design iterations on the optical or mechanical design.
Approach: We propose a TCE utilizing exclusively reflective optics to focus and steer light from and to a double-clad fiber. Specifically, we use an ellipsoidal mirror to achieve finite conjugation between the fiber tip and the imaging plane.
Results: We demonstrate a functional all-reflective TCE. We first detail the design, fabrication, and assembly steps required to obtain such a device. We then characterize its performance and demonstrate combined OCT at 1300 nm and visible spectroscopic imaging in the 500- to 700-nm range. Finally, we discuss the advantages and limitations of the proposed design.
Conclusions: An all-reflective TCE is feasible and allows for achromatic high-quality imaging. Such a device could be utilized as a platform for testing various combinations of modalities to identify the optimal candidates without requiring design iterations.
期刊介绍:
The Journal of Biomedical Optics publishes peer-reviewed papers on the use of modern optical technology for improved health care and biomedical research.