母乳中乳铁蛋白和溶菌酶的浓度随膳食干预而变化。

IF 4.8 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Nutritional Biochemistry Pub Date : 2024-09-07 DOI:10.1016/j.jnutbio.2024.109760
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引用次数: 0

摘要

众所周知,母乳(HM)1 中的抗菌蛋白成分在哺乳期会发生变化。然而,母体饮食对这些抗菌蛋白(尤其是乳铁蛋白和溶菌酶)的影响仍然未知。此外,乳铁蛋白和溶菌酶的浓度是否存在日变化、昼夜变化和乳房间变化也不清楚。我们研究了低糖、低脂、高纤维饮食干预对乳腺组织溶菌酶和乳铁蛋白浓度的影响。在为期三周的时间里,我们每天在不同时间从两个乳房采集乳腺组织样本,以测量个体内部的差异水平。干预措施大大降低了母亲的糖、总脂肪和饱和脂肪摄入量。在干预过程中,HM 乳铁蛋白浓度明显下降,但影响相对较小。此外,乳铁蛋白和溶菌酶的浓度随时间变化,在一天之内和一天之间有显著差异,但在不同乳房之间没有差异。
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Human milk lactoferrin and lysozyme concentrations vary in response to a dietary intervention
It is known that human milk (HM)1 antimicrobial protein composition varies during lactation. However, the impact of maternal diet on these antimicrobial proteins, particularly lactoferrin and lysozyme remains unknown. In addition, it is unclear whether daily, circadian, and between breast variations exist for lactoferrin and lysozyme concentrations. We investigated the impact of a low sugar, low fat, high fibre dietary intervention on HM lysozyme and lactoferrin concentrations. HM was sampled across a 3-week period; daily, at different times of day, and from both breasts to measure the level of intraindividual variation. The intervention significantly reduced maternal sugar, total fat, and saturated fat intake. HM lactoferrin concentration declined significantly over the course of the intervention however the effect size was relatively small. In addition, lactoferrin and lysozyme concentrations were variable over time, and differed significantly within and across the day but not between breasts.
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来源期刊
Journal of Nutritional Biochemistry
Journal of Nutritional Biochemistry 医学-生化与分子生物学
CiteScore
9.50
自引率
3.60%
发文量
237
审稿时长
68 days
期刊介绍: Devoted to advancements in nutritional sciences, The Journal of Nutritional Biochemistry presents experimental nutrition research as it relates to: biochemistry, molecular biology, toxicology, or physiology. Rigorous reviews by an international editorial board of distinguished scientists ensure publication of the most current and key research being conducted in nutrition at the cellular, animal and human level. In addition to its monthly features of critical reviews and research articles, The Journal of Nutritional Biochemistry also periodically publishes emerging issues, experimental methods, and other types of articles.
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