皮肤表面局部炎症的生物标志物可预测压疮和糖尿病足溃疡。

IF 1.5 4区 医学 Q3 DERMATOLOGY Journal of wound care Pub Date : 2024-09-02 DOI:10.12968/jowc.2024.0127
Pauline Wilson, Declan Patton, Tom O'Connor, Fiona Boland, Aglecia Mv Budri, Zena Moore, Niamh Phelan
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引用次数: 0

摘要

本评论探讨了压疮(PUs)和糖尿病足溃疡(DFUs)之间存在的相似之处。它旨在描述这些伤口类型在理论和实践上的共同点。报告还详细介绍了炎症在这两种伤口类型中的作用。由于行动不便或医疗设备的原因,PU 会在长期暴露于压力或压力与剪切力的作用下发生。因此会发生炎症,造成细胞损伤。DFU 与行动不便无关,但与糖尿病并发症导致的行动不便有关。在多病并发的情况下,这两种病变的发病率和流行率都会增加。预测这两种类型的溃疡都具有挑战性。据报道,目前的风险评估方法无法有效预测溃疡发生的时间。虽然全身性炎症很容易测量,但局部或亚临床炎症的存在却很难辨别。在面临 DFU 或 PU 风险的患者中,炎症的临床症状和体征可能会被掩盖,而且在溃疡出现之前,全身炎症生物标志物的升高可能不足以预测即将发生的损害。目前的文献表明,使用皮肤表面的局部炎症生物标志物(即水肿和温度)可以识别早期的组织损伤。
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Biomarkers of local inflammation at the skin's surface may predict both pressure and diabetic foot ulcers.

This commentary considers the similarities which exist between pressure ulcers (PUs) and diabetic foot ulcers (DFUs). It aims to describe what is known to be shared-both in theory and practice-by these wound types. It goes on to detail the literature surrounding the role of inflammation in both wound types. PUs occur following prolonged exposure to pressure or pressure in conjunction with shear, either due to impaired mobility or medical devices. As a result, inflammation occurs, causing cell damage. While DFUs are not associated with immobility, they are associated with altered mobility occurring as a result of complications of diabetes. The incidence and prevalence of both types of lesions are increased in the presence of multimorbidity. The prediction of either type of ulceration is challenging. Current risk assessment practices are reported to be ineffective at predicting when ulceration will occur. While systemic inflammation is easily measured, the presence of local or subclinical inflammation is harder to discern. In patients at risk of either DFUs or PUs, clinical signs and symptoms of inflammation may be masked, and systemic biomarkers of inflammation may not be elevated sufficiently to predict imminent damage until ulceration appears. The current literature suggests that the use of local biomarkers of inflammation at the skin's surface, namely oedema and temperature, may identify early tissue damage.

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来源期刊
Journal of wound care
Journal of wound care DERMATOLOGY-
CiteScore
2.90
自引率
10.50%
发文量
215
期刊介绍: Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice. In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers. Specifically, JWC publishes: High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments Clinical case studies providing information on how to deal with complex wounds Comprehensive literature reviews on current concepts and practice, including cost-effectiveness Updates on the activities of wound care societies around the world.
期刊最新文献
Using patient-reported experiences to inform the use of foam dressings for hard-to-heal wounds: perspectives from a wound care expert panel. Wound healing after surgical therapy for multiple myeloma: a case-control study. A dedicated wound care module for third-year baccalaureate nurses: does it increase their knowledge and confidence? A new portable negative pressure wound therapy device: a prospective study investigating clinical outcomes. Biofilms and antibacterial sutures.
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