Yubo Xiao, Zhaotun Hu, Hang Liu, Xinglin Jiang, Taimei Zhou, Haiying Wang, Heng Long, Ming Li
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引用次数: 0
摘要
茯苓又名玉苓、松柏,是茯苓科植物茯苓的干燥菌核,寄生于松树根部。古人称其为 "四时药",因其功效广泛,可与多种药物配伍。茯苓酸(PA)是茯苓的主要生物化合物之一。研究表明,PA 具有多种药理特性,包括抗炎和抗氧化。最近,PA 因其抗癌特性而备受关注。研究人员发现,PA 在体外和体内通过调节细胞凋亡和细胞周期而显示出抗癌活性。将 PA 与抗癌药物、放射治疗和生物材料一起使用,还可以提高癌细胞的敏感性,延缓癌症的发展。本综述旨在参考已发表的文献,总结 PA 的抗癌机制。对所收集数据的审查表明,PA 有潜力发展成为一种有效的抗癌剂。
Poria cocos, also known as Jade Ling and Songbai taro, is a dry fungus core for Wolfiporia cocos, which is parasitic on the roots of pine trees. The ancients called it "medicine of four seasons" because of its extensive effect and ability to be combined with many medicines. Pachymic acid (PA) is one of the main biological compounds of Poria cocos. Research has shown that PA has various pharmacological properties, including anti-inflammatory and antioxidant. PA has recently attracted much attention due to its anticancer properties. Researchers have found that PA showed anticancer activity by regulating apoptosis and the cell cycle in vitro and in vivo. Using PA with anticancer drugs, radiotherapy, and biomaterials could also improve the sensitivity of cancer cells and delay the progression of cancer. The purpose of this review was to summarize the anticancer mechanism of PA by referencing the published documents. A review of the collected data indicated that PA had the potential to be developed into an effective anticancer agent.
期刊介绍:
Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties.
As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.