Wantong Xu, Minghe Ouyang, Dan Peng, Zhongbiao Jiang
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引用次数: 0
摘要
流行病学和其他研究表明,类风湿关节炎(RA)的发生和发展与饮食密切相关。为了进一步探讨饮食习惯与类风湿关节炎之间的因果关系,我们进行了双向孟德尔随机化(MR)分析。与饮食习惯相关的数据集来自全基因组关联研究,包括 143 种饮食习惯。有关 RA 的数据集来自 FinnGen 数据库。反方差加权(IVW)、MR-Egger、简单模式、加权中位数和加权模式被用于双样本、双向 MR 分析。同时,为确保结果的准确性,还使用了多种多向性和异质性检验。IVW结果显示,在当前饮酒者中(通常在进餐时饮酒,是 + 有变化 vs 否)与RA呈正相关(β,0.563 [95% 置信区间 [CI],0.286-0.840];P = 6.7 × 10-5)。涂抹类型(低脂涂抹与其他涂抹)与 RA 呈负相关(β,-2.536 [95% CI,-3.725 至-1.346];P = 2.9 × 10-5)。此外,反向 MR 结果显示,RA 与牛奶类型呈正相关(脱脂牛奶与其他牛奶;β,0.006 [95% CI,0.000-0.011];P = 4.5 × 10-2)。RA与涂抹类型呈正相关(桶装人造奶油与从不涂抹;β,0.016 [95% CI,0.002-0.029];P = 2.5 × 10-2)。多向性和异质性检验结果表明,所得结果不存在多向性(P > .05)。MR-Egger、简单模式、加权中位数和加权模式的分析结果与我们的 IVW 结果一致。本研究揭示了特定饮食习惯与 RA 之间的潜在联系。在经常饮酒者中(通常在进餐时饮酒,是 + 有差异 vs 否)与 RA 呈正相关。涂抹酱类型(低脂涂抹酱与其他)与 RA 呈负相关。RA 与牛奶类型(脱脂牛奶与其他牛奶)和涂抹类型(桶装人造黄油与从不涂抹)呈正相关。
Bidirectional Mendelian randomization explores the causal relationship between dietary habits and rheumatoid arthritis.
Epidemiological and other studies have shown that the occurrence and progression of rheumatoid arthritis (RA) are closely related to diet. To further explore the causal association between dietary habits and RA, we performed a bidirectional Mendelian randomization (MR) analysis. The dataset related to dietary habits is from genome-wide association studies, including 143 dietary habits. The dataset of RA is from the FinnGen database. Inverse variance weighted (IVW), MR-Egger, simple mode, weighted median, and weighted mode were used for the 2-sample, 2-way MR analysis. At the same time, a variety of pleiotropic and heterogeneity tests were used to ensure the accuracy of the results. IVW results show that among current drinkers (drinks usually with meals yes + it varies vs no) was positively correlated with RA (β, 0.563 [95% confidence interval [CI], 0.286-0.840]; P = 6.7 × 10-5). Spread type (low fat spread vs any other) was negatively correlated with RA (β, -2.536 [95% CI, -3.725 to -1.346]; P = 2.9 × 10-5). In addition, the reverse MR results showed that RA was positively correlated with milk type (skimmed vs any other; β, 0.006 [95% CI, 0.000-0.011]; P = 4.5 × 10-2). RA was positively correlated with spread type (tub margarine vs never; β, 0.016 [95% CI, 0.002-0.029]; P = 2.5 × 10-2). The results of pleiotropy and heterogeneity tests showed that there was no pleiotropy (P > .05) in the obtained results. The analysis results of MR-Egger, simple mode, weighted median, and weighted mode are consistent with our IVW results. This study reveals a potential association between specific dietary habits and RA. Among current drinkers (drinks usually with meals yes + it varies vs no) was positively correlated with RA. Spread type (low fat spread vs any other) was negatively correlated with RA. RA was positively correlated with milk type (skimmed vs any other) and spread type (tub margarine vs never).
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