Federica Arienti, Giovanni Casazza, Giulia Franco, Giulia Lazzeri, Edoardo Monfrini, Alessandro Di Maio, Roberto Erro, Paolo Barone, Filippo Tamma, Elena Caputo, Maria Antonietta Volontè, Laura Cacciaguerra, Andrea Pilotto, Alessandro Padovani, Cristoforo Comi, Luca Magistrelli, Franco Valzania, Francesco Cavallieri, Laura Avanzino, Roberta Marchese, Mariachiara Sensi, Giorgia Carroli, Roberto Eleopra, Roberto Cilia, Francesca Spagnolo, Alessandro Tessitore, Rosa De Micco, Roberto Ceravolo, Giovanni Palermo, Maria Chiara Malaguti, Leonardo Lopiano, Pierluigi Tocco, Chiara Sorbera, Michele Tinazzi, Andrea Ciammola, Donatella Ottaviani, Enza Maria Valente, Alberto Albanese, Fabio Blandini, Margherita Canesi, Angelo Antonini, Miryam Carecchio, Vincenza Fetoni, Carlo Colosimo, Daniele Volpe, Nicola Tambasco, Giovanni Cossu, Mario Zappia, Alessio Di Fonzo
{"title":"帕金森病的家族史：全国横断面研究","authors":"Federica Arienti, Giovanni Casazza, Giulia Franco, Giulia Lazzeri, Edoardo Monfrini, Alessandro Di Maio, Roberto Erro, Paolo Barone, Filippo Tamma, Elena Caputo, Maria Antonietta Volontè, Laura Cacciaguerra, Andrea Pilotto, Alessandro Padovani, Cristoforo Comi, Luca Magistrelli, Franco Valzania, Francesco Cavallieri, Laura Avanzino, Roberta Marchese, Mariachiara Sensi, Giorgia Carroli, Roberto Eleopra, Roberto Cilia, Francesca Spagnolo, Alessandro Tessitore, Rosa De Micco, Roberto Ceravolo, Giovanni Palermo, Maria Chiara Malaguti, Leonardo Lopiano, Pierluigi Tocco, Chiara Sorbera, Michele Tinazzi, Andrea Ciammola, Donatella Ottaviani, Enza Maria Valente, Alberto Albanese, Fabio Blandini, Margherita Canesi, Angelo Antonini, Miryam Carecchio, Vincenza Fetoni, Carlo Colosimo, Daniele Volpe, Nicola Tambasco, Giovanni Cossu, Mario Zappia, Alessio Di Fonzo","doi":"10.1002/mdc3.14206","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Family history of Parkinson's disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect.</p><p><strong>Objectives: </strong>We investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD).</p><p><strong>Methods: </strong>A cross-sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected.</p><p><strong>Results: </strong>Family history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group.</p><p><strong>Conclusions: </strong>fPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"1434-1440"},"PeriodicalIF":2.6000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542285/pdf/","citationCount":"0","resultStr":"{\"title\":\"Family History in Parkinson's Disease: A National Cross-Sectional Study.\",\"authors\":\"Federica Arienti, Giovanni Casazza, Giulia Franco, Giulia Lazzeri, Edoardo Monfrini, Alessandro Di Maio, Roberto Erro, Paolo Barone, Filippo Tamma, Elena Caputo, Maria Antonietta Volontè, Laura Cacciaguerra, Andrea Pilotto, Alessandro Padovani, Cristoforo Comi, Luca Magistrelli, Franco Valzania, Francesco Cavallieri, Laura Avanzino, Roberta Marchese, Mariachiara Sensi, Giorgia Carroli, Roberto Eleopra, Roberto Cilia, Francesca Spagnolo, Alessandro Tessitore, Rosa De Micco, Roberto Ceravolo, Giovanni Palermo, Maria Chiara Malaguti, Leonardo Lopiano, Pierluigi Tocco, Chiara Sorbera, Michele Tinazzi, Andrea Ciammola, Donatella Ottaviani, Enza Maria Valente, Alberto Albanese, Fabio Blandini, Margherita Canesi, Angelo Antonini, Miryam Carecchio, Vincenza Fetoni, Carlo Colosimo, Daniele Volpe, Nicola Tambasco, Giovanni Cossu, Mario Zappia, Alessio Di Fonzo\",\"doi\":\"10.1002/mdc3.14206\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Family history of Parkinson's disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect.</p><p><strong>Objectives: </strong>We investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD).</p><p><strong>Methods: </strong>A cross-sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected.</p><p><strong>Results: </strong>Family history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group.</p><p><strong>Conclusions: </strong>fPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.</p>\",\"PeriodicalId\":19029,\"journal\":{\"name\":\"Movement Disorders Clinical Practice\",\"volume\":\" \",\"pages\":\"1434-1440\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542285/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Movement Disorders Clinical Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/mdc3.14206\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/9/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Movement Disorders Clinical Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/mdc3.14206","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/13 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Family History in Parkinson's Disease: A National Cross-Sectional Study.
Background: Family history of Parkinson's disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect.
Objectives: We investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD).
Methods: A cross-sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected.
Results: Family history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group.
Conclusions: fPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.
期刊介绍：
Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)
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