Metabolite dependence of antibiotic susceptibility in a gut microbe.

Antibiotics save lives but can have unwanted effects on our gut microbes, thereby contributing to disease. A mechanistic understanding of how such microbes respond to antibiotics is hence critical. Recently in mSphere, Nilson et al. investigated the metabolite dependence of antibiotic susceptibility in Bacteroides thetaiotaomicron, an abundant and important member of our gut microbiota (R. Nilson, S. Penumutchu, F. S. Pagano, and P. Belenky, mSphere 9:e00103-24, 2024, https://doi.org/10.1128/msphere.00103-24). Their uncovered findings suggest the possibility of potentiating antibiotics with metabolites to reduce post-antibiotic "blooming" of B. thetaiotaomicron and the associated development of gut symbiosis.