E Girmanova, J Duskova, P Mrazova, M Fialova, O Viklicky, P Hruba
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引用次数: 0
摘要
测量 T 细胞反应可以补充抗体检测结果所提供的抗病毒免疫信息。该研究评估了第三剂 mRNA COVID-19 疫苗对肾移植受者（25 名 KTR）与健康对照组（26 名 Hc）的 T 细胞应答和抗体产生的影响。结果显示，KTRs（p=0.025）和Hc（p=0.009）中的S激活CD4+CD154+IFN?+TNF?+双生产者细胞均明显增加，KTRs（p=0.00019）和Hc（p=3.10-8）中的尖峰抗体反应也在第三剂后的第三个月有所增加。此外，研究还发现血清阴性的 KTR（无应答者）从第三剂前的 9/25（36%）下降到第三剂后 3 个月的 2/25（7%），而第二剂后 5/9（56%）的无应答者出现了特异性 T 细胞应答。值得注意的是，第三剂明显提高了KTR和Hc的血清转换率，尽管Hc个体表现出更高的抗体水平。关键词：mRNA COVID-19 疫苗、T 细胞、SARS-CoV-2 抗体、肾移植、mRNA 疫苗接种。
The Impact of COVID-19 Third Dose Vaccination on the Magnitude of Antigen Specific T Cells in Kidney Transplant Patients.
Measuring T cell response can add information about antivirus immunity provided by antibody test results. The study evaluates the impact of a third mRNA COVID-19 vaccine dose on T cell response and antibody production in kidney transplant recipients (25 KTRs) versus healthy controls (26 Hc). Results show a significant rise in S-activated CD4+CD154+IFN?+TNF?+ double producer cells in both KTRs (p=0.025) and Hc (p=0.009) as well as increased spike antibody response in KTRs (p=0.00019) and Hc (p=3.10-8) third-month post-third dose. Moreover, the study revealed a drop in seronegative KTRs (non-responders) from 9/25 (36%) pre-third dose to 2/25 (7%) at 3 months post-third dose while 5/9 (56%) of non-responders post-second dose showed specific T cell responses. Notably, the third dose significantly improved seroconversion rates in both KTRs and Hc, although Hc individuals exhibited higher antibody levels. Key words: mRNA COVID-19 vaccine, T cells, SARS-CoV-2 antibodies, Kidney transplantation, mRNA vaccination.
期刊介绍：
Physiological Research is a peer reviewed Open Access journal that publishes articles on normal and pathological physiology, biochemistry, biophysics, and pharmacology.
Authors can submit original, previously unpublished research articles, review articles, rapid or short communications.
Instructions for Authors - Respect the instructions carefully when submitting your manuscript. Submitted manuscripts or revised manuscripts that do not follow these Instructions will not be included into the peer-review process.
The articles are available in full versions as pdf files beginning with volume 40, 1991.
The journal publishes the online Ahead of Print /Pre-Press version of the articles that are searchable in Medline and can be cited.
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