采用横向耻骨前岛瓣尿道成形术进行小儿尿道下裂初级修复术后出现并发症的时间。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-08-31 Epub Date: 2024-08-26 DOI:10.21037/tau-24-135
Jian Zhao, Ning Sun, Weiping Zhang, Hongcheng Song
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引用次数: 0

摘要

背景:尿道下裂是男性最常见的先天性畸形之一:尿道下裂是男性最常见的先天性畸形之一。阴茎前横行尿道岛成形术因其方便的阴茎包皮,在中国被广泛应用,尤其适用于中度和重度病例。本分析旨在探讨横向阴茎前尿道岛成形术后首次并发症的发生时间:我们回顾性分析了2018年12月至2019年12月在首都医科大学附属北京儿童医院接受经阴茎前横行尿道岛成形术修复尿道下裂的患儿的临床资料和随访结果。术后并发症包括尿道瘘、尿道憩室、尿道狭窄、顽固性软下疳。采用Kaplan-Meier生存曲线对临床变量和并发症发生时间进行单变量分析:结果:共发现 165 例患者。在随访期间,101 例患者(61.2%)出现了并发症。94%的并发症发生在1年内。在出现并发症的患儿中,Kaplan-Meier生存分析表明,年龄小于18个月和尿道下裂的严重程度具有统计学意义(分别为P=0.005和P=0.04)。尿道憩室的发生时间明显长于尿道瘘和尿道狭窄:结论:尿道下裂横向耻骨前尿道岛成形术后90%以上的并发症发生在1年内,其中与近端尿道下裂相关的并发症发生时间早于中轴/远端尿道下裂。外科医生可考虑在术后第一年内进行更频繁的随访,以尽早发现这些并发症。
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Time to complication after primary pediatric hypospadias repair with transverse preputial island flap urethroplasty.

Background: Hypospadias is one of the most common congenital malformations in men. The transverse preputial island urethroplasty is widely used in China, especially for moderate and severe cases due to its convenient prepuce of the penis. This analysis aims to delineate the time to first complication following transverse preputial island urethroplasty.

Methods: We analyzed the clinical data and follow-up results of children who underwent hypospadias repair by transverse preputial island urethroplasty in Beijing Children's Hospital, Capital Medical University from December 2018 to December 2019 retrospectively. Postoperative complications included urethral fistula, urethral diverticulum, urethral stricture, persistent chordee. Univariate analysis of clinical variables and time to complication was performed using Kaplan-Meier survival curve.

Results: One hundred and sixty-five patients were identified. During the follow-up period, complications occurred in 101 cases (61.2%). Ninety-four percent of complications occurred within 1 year. Among children who experienced complications, Kaplan-Meier survival analysis showed that age less than 18 months and the severity of hypospadias were statistically significant (P=0.005 and P=0.04, respectively). The time to urethral diverticulum was significantly longer than that of urethral fistula and urethral stricture.

Conclusions: More than 90% of complications after the transverse preputial island urethroplasty of hypospadias occurred within 1 year, with those related to proximal hypospadias presenting earlier than those of midshaft/distal hypospadias. Surgeons may consider a more frequent follow-up within the first year after surgery to detect these complications as early as possible.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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