[血管化眼窝区：发生率和结构特征]。

Q3 Medicine Vestnik oftalmologii Pub Date : 2024-01-01 DOI:10.17116/oftalma20241400415

A N Stulova, N S Semenova, V S Akopyan

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引用次数: 0

摘要

目的：本研究旨在评估血管化眼窝区（包括黄斑-眼窝毛细血管（MFC）和先天性视网膜大血管（CRM））的患病率，并分析MFC患者黄斑区的结构特征：研究的第一阶段评估了MFC和CRM的患病率。进行了光学相干断层血管造影（OCT-A），并分析了眼窝无血管区的 OCT-A 图像。第二阶段分为两组：MFC 组（12 眼，9 名患者，平均年龄（43.8±10.7）岁）和对照组（18 眼，17 名患者，平均年龄（43.0±11.8）岁）。对视网膜中央厚度（CRT）、视网膜神经纤维层（RNFL）、神经节细胞层（GCL）、内丛状层（IPL）、内核层（INL）、外丛状层（OPL）、外核层（ONL）和眼窝凹深度进行了比较分析：在 536 名患者的 1031 只眼睛样本中，有 45 只眼睛检测到了 MFC。3名患者的3只眼睛出现了CRM。MFC 组视网膜下旁区（26.50 [26.00; 29.50] 和 24.50 [21.75; 26.50] μm；p=0.022）和视网膜区（15.50 [14.00; 16.00] 和 12.00 [11.00; 14.00] μm；p=0.017）的 RNFL 厚度明显更高。此外，MFC 患者在眼窝、下眼窝、鼻侧和颞侧眼窝旁的 GCL 和 IPL 厚度较高。与对照组相比，MFC 组的眼窝凹陷深度明显较低（83.0 [77.4; 101.6] 和 128.0 [107.5; 147.05] μm；P=0.001）：MFC的发病率为4.36%（按眼数计算），而CRM的发病率为0.29%。MFC患者的黄斑区视网膜内层厚度增加，眼窝深度减小，这表明胚胎发育过程中神经节细胞迁移和凋亡的自然过程可能受到干扰。

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[Vascularized foveal zone: prevalence and structural characteristics].

Purpose: This study was performed to assess the prevalence of the vascularized foveal zone, including macular-foveal capillaries (MFC) and congenital retinal macrovessels (CRM), and to analyze the structural characteristics of the macular area in patients with MFC.

Material and methods: The first phase of the study evaluated the prevalence of MFC and CRM. Optical coherence tomography angiography (OCT-A) was performed, and OCT-A images of the foveal avascular zone were analyzed. In the second phase, two groups were formed: the MFC group (12 eyes, 9 patients, mean age 43.8±10.7 years) and the control group (18 eyes, 17 patients, mean age 43.0±11.8 years). A comparative analysis was performed assessing central retinal thickness (CRT), thickness of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), and foveal pit depth.

Results: MFCs were detected in 45 eyes from a total sample of 1031 eyes of 536 patients. The presence of CRM was recorded in three eyes of three patients. RNFL thickness was significantly higher in the MFC group in the inferior parafoveal sector (26.50 [26.00; 29.50] and 24.50 [21.75; 26.50] μm; p=0.022) and in the foveal zone (15.50 [14.00; 16.00] and 12.00 [11.00; 14.00] μm; p=0.017). Additionally, patients with MFC had a higher thickness of GCL and IPL in the fovea, inferior, nasal, and temporal parafoveal sectors. The depth of the foveal pit was significantly lower in the MFC group compared to the control group (83.0 [77.4; 101.6] and 128.0 [107.5; 147.05] μm; p=0.001).

Conclusion: The prevalence of MFC was 4.36% (calculated per number of eyes), while the prevalence of CRM - 0.29%. The macular area in patients with MFC had increased thickness of the inner retinal layers and decreased depth of the foveal pit, suggesting potential disruption in the natural process of ganglion cell migration and apoptosis during embryogenesis.

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来源期刊

Vestnik oftalmologii Medicine-Ophthalmology

CiteScore

0.80

自引率

0.00%

发文量

129

期刊介绍： The journal publishes materials on the diagnosis and treatment of eye diseases, hygiene of vision, prevention of ophthalmic affections, history of Russian ophthalmology, organization of ophthalmological aid to the population, as well as the problems of special equipment. Original scientific articles and surveys on urgent problems of theory and practice of Russian and foreign ophthalmology are published. The journal contains book reviews on ophthalmology, information on the activities of ophthalmologists" scientific societies, chronicle of congresses and conferences.The journal is intended for ophthalmologists and scientific workers dealing with clinical problems of diseases of the eye and physiology of vision.