[关于大血管炎成像的新闻]。

IF 0.9 4区 医学 Q4 RHEUMATOLOGY Zeitschrift fur Rheumatologie Pub Date : 2024-09-13 DOI:10.1007/s00393-024-01565-0
Valentin S Schäfer, Simon M Petzinna, Wolfgang A Schmidt
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引用次数: 0

摘要

大血管脉管炎,包括巨细胞动脉炎(GCA)和高安动脉炎(TAK),是主要影响主动脉及其分支的自身免疫性疾病。GCA 是最常见的原发性血管炎。血管壁的炎症变化可导致严重的并发症,如无脑、中风、主动脉夹层和破裂。成像技术已成为诊断和监测大血管炎不可或缺的一部分,可对疾病进行有效监测。GCA 和 TAK 表现出相似的血管分布模式。但是,TAK从未累及颞动脉,而腋动脉炎在GCA中更常发生。在大多数中心,颞动脉和腋动脉的超声检查已取代颞动脉活检,成为 GCA 的主要诊断工具。除超声波外,磁共振成像(MRI)、计算机断层扫描(CT)和[18F]-FDG(氟脱氧葡萄糖)正电子发射断层扫描-计算机断层扫描(PET)也很重要,尤其是在观察主动脉方面。此外,PET-CT 现在也能对颞动脉进行评估,但尚未广泛应用。在多发性风湿痛(PMR)中,肩部和髋部的超声波检查是 ACR/EULAR 分类标准的一部分。核磁共振成像可详细观察到关节外的其他炎症表现,显示粘膜、肌腱和韧带的特征性炎性病变。[18F]-FDG-PET-CT也能显示肌肉骨骼炎症,尤其是肩部和髋部以及椎旁区域。超声波可在多达23%的PMR患者中检测出亚临床GCA,这种情况应像GCA一样进行治疗。新的放射性钙离子和改进的核磁共振成像等技术创新可进一步加强对大血管炎和 PMR 的诊断和监测,从而通过更快地开始治疗在改善预后方面发挥重要作用。
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[News on the imaging of large vessel vasculitis].

Large vessel vasculitis, including giant cell arteritis (GCA) and Takayasu arteritis (TAK), are autoimmune diseases primarily affecting the aorta and its branches. GCA is the most common primary vasculitis. Inflammatory changes in the vessel walls can cause serious complications such as amaurosis, stroke, and aortic dissection and rupture. Imaging techniques have become an integral part for the diagnosis and monitoring of large vessel vasculitis, allowing for effective disease monitoring. GCA and TAK exhibit similar patterns of vascular distribution. However, the temporal arteries are never involved in TAK, and axillary arteritis occurs more frequently in GCA. In most centers, ultrasound of the temporal and axillary arteries has replaced temporal artery biopsy as the primary diagnostic tool for GCA. In addition to ultrasound, magnetic resonance imaging (MRI), computed tomography (CT), and [18F]-FDG (fluorodeoxyglucose) positron emission tomography-computed tomography (PET) are important, particularly for visualizing the aorta. Moreover, PET-CT is now also capable of assessing the temporal arteries, although it is not yet widely available. In polymyalgia rheumatica (PMR), ultrasound of the shoulder and hip regions is part of the ACR/EULAR classification criteria. MRI allows detailed visualization of additional inflammatory extraarticular manifestations, showing characteristic inflammatory lesions in entheses, tendons, and ligaments. [18F]-FDG-PET-CT also enables the visualization of musculoskeletal inflammation, especially in the shoulder and hip regions, as well as paravertebral areas. Ultrasound can detect subclinical GCA in up to 23% of patients with PMR, which should be treated like GCA. Technological innovations such as new radiotracers and improved MRI imaging could further enhance the diagnosis and monitoring of large vessel vasculitis and PMR, thus playing a crucial role in improving the prognosis through faster initiation of therapy.

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来源期刊
Zeitschrift fur Rheumatologie
Zeitschrift fur Rheumatologie 医学-风湿病学
CiteScore
2.20
自引率
20.00%
发文量
150
审稿时长
6-12 weeks
期刊介绍: Die Zeitschrift für Rheumatologie ist ein international angesehenes Publikationsorgan und dient der Fortbildung von niedergelassenen und in der Klinik tätigen Rheumatologen. Die Zeitschrift widmet sich allen Aspekten der klinischen Rheumatologie, der Therapie rheumatischer Erkrankungen sowie der rheumatologischen Grundlagenforschung. Umfassende Übersichtsarbeiten zu einem aktuellen Schwerpunktthema sind das Kernstück jeder Ausgabe. Im Mittelpunkt steht dabei gesichertes Wissen zu Diagnostik und Therapie mit hoher Relevanz für die tägliche Arbeit – der Leser erhält konkrete Handlungsempfehlungen. Frei eingereichte Originalien ermöglichen die Präsentation wichtiger klinischer Studien und dienen dem wissenschaftlichen Austausch.
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