碳-离子放射治疗对乳腺癌的价值。

IF 2.1 Q3 ONCOLOGY International Journal of Particle Therapy Pub Date : 2024-08-30 eCollection Date: 2024-12-01 DOI:10.1016/j.ijpt.2024.100629
Bowen Yu, Kai-Wen Li, Yingyi Fan, Xiaohua Pei
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引用次数: 0

摘要

为了探讨碳离子放射治疗(CIRT)在乳腺癌中的挑战和前景,我们在这篇综述中总结了碳离子放射治疗乳腺癌的非临床和临床研究进展。共有 6 项非临床研究表明,与 X 射线相比,碳离子照射对乳腺癌细胞系(包括三阴性乳腺癌和人表皮生长因子受体 2 阴性乳腺癌)的效果更好。体外研究表明,与 Hh 抑制剂、双重酪氨酸激酶抑制剂和 PARP 抑制剂联合使用很有前景。据 5 项临床研究报告,约有 34 名乳腺癌患者接受了 CIRT 治疗。所有研究都表明,治疗效果良好,风险可接受且可控。在这些研究中,共有 21 名患者进行了治疗后反应评估,其中 19 名患者(90.48%)报告了完全反应或部分反应。完全应答率为 66.67%。完全应答的时间从 3 个月到 24 个月不等。在这些研究中,除了 21 名患者中有 14 名(66.67%)出现 1 级急性皮肤反应外,未观察到其他不良反应。虽然某些研究中出现应答的时间比预期的要长,但持续的应答和令人满意的安全性为进一步研究这种新疗法提供了依据。
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Value of Carbon-Ion Radiation Therapy for Breast Cancer.

To explore the challenges and future of carbon-ion radiation therapy (CIRT) in breast cancer, we summarized the progress of nonclinical and clinical studies on CIRT for breast cancer in this review. A total of 6 nonclinical studies have been reported, which demonstrated a better effect of Carbon-ion irradiation compared with X-ray in breast cancer cell lines (including triple-negative breast cancer and Human Epidermal Growth Factor Receptor 2-negative breast cancer). Combination with Hh inhibitor, dual tyrosine kinase inhibitor, and PARP inhibitor is promising as demonstrated in the in vitro studies. Approximately 34 patients with breast cancer went through CIRT treatment, as reported in 5 clinical studies. All studies demonstrated promising treatment effects with acceptable and manageable risks. In these studies, a total of 21 patients were reported with post-treatment response assessments, among whom 19 patients (90.48%) reported a response of complete response or partial response. The complete response rate was 66.67%. The time to complete the response ranged from 3 months to 24 months. No adverse events were observed in these studies except for grade 1 acute skin reaction in 14 out of the 21 patients (66.67%). Although the time to respond was longer than expected in some studies, the persistent responses and satisfactory safety profile provided the rationale for further research on this new therapy.

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来源期刊
International Journal of Particle Therapy
International Journal of Particle Therapy Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
3.70
自引率
5.90%
发文量
23
审稿时长
20 weeks
期刊最新文献
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