慢性丙型肝炎患者体内抗酵母菌抗体的高频率。

IF 1.1 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY Arab Journal of Gastroenterology Pub Date : 2024-09-16 DOI:10.1016/j.ajg.2024.07.013

Mariam Ghozzi, Amani Mankai, Fatma Mechi, Zeineb Ben Chedly, Ouafa Kallala, Sarra Melayah, Abdelhalim Trabelsi, Ibtissem Ghedira

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引用次数: 0

摘要

背景和研究目的：慢性丙型肝炎（CHC）是由丙型肝炎病毒引起的肝病。抗酿酒酵母（S. cerevisiae）抗体（ASCA）经常见于自身免疫性疾病，但很少见于病毒感染。我们旨在确定CHC成年患者中ASCA的频率：本研究纳入了 88 名 CHC 患者和 160 名健康献血者。采用酶联免疫吸附试验测定ASCA-IgG和IgA水平。统计分析采用开放式 EPI 3 版软件。结果：31.8%的患者和 3.7%的对照组存在 ASCA（IgG 或 IgA）（p -6）。CHC患者中ASCA-IgG和ASCA-IgA的出现率高于健康人（分别为23.9%对3.1%；p -5和9.1%对0.6%；p = 0.002）。在患者中，ASCA-IgG 和 IgA 的平均水平显著高于对照组（分别为 9.95 ± 11.78 U U/mL vs. 2.28 ± 2.86 U U/mL, p -6 和 5.96 ± 7.69 U U/mL vs. 0.56 ± 0.12 U U/mL, p -6；）。CHC患者的ASCA-IgG平均水平显著高于ASCA-IgA（9.95 ± 11.78 U U/mL vs. 5.96 ± 7.69 U U/mL, p = 0.008）：结论：CHC患者的ASCA发生率明显高于健康对照组。

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High frequency of anti-Saccharomyces cerevisiae antibodies in chronic hepatitis C.

Background and study aim: Chronic hepatitis C (CHC) is a liver disease caused by the hepatitis C virus. Anti-Saccharomyces cerevisiae (S. cerevisiae) antibodies (ASCA) are frequently reported in autoimmune diseases but rarely in viral infections. We aimed to determine the frequency of ASCA in adult patients with CHC.

Patients and methods: Eighty-eight patients with CHC and 160 healthy blood donors were included in this study. ASCA-IgG and IgA levels were determined using enzyme linked immunosorbent assay. For statistical analysis, we used open EPI version 3 as software. Correlations were determined by Spearman's test using IBM® SPSS® Statistics.

Results: ASCA (IgG or IgA) were present in 31.8 % of patients and in 3.7 % of controls (p < 10^-6). ASCA-IgG and ASCA-IgA were more frequent in patients with CHC than in healthy subjects (23.9 % vs. 3.1 %; p < 10^-5 and 9.1 % vs. 0.6 %; p = 0.002, respectively). In patients, mean levels of ASCA-IgG and IgA were significantly higher than in controls (9.95 ± 11.78 U/mL vs. 2.28 ± 2.86 U/mL, p < 10^-6 and 5.96 ± 7.69 U/mL vs. 0.56 ± 0.12 U/mL, p < 10^-6; respectively). In patients with CHC, the mean level of ASCA-IgG was significantly higher than that of ASCA-IgA (9.95 ± 11.78 U/mL vs. 5.96 ± 7.69 U/mL, p = 0.008).

Conclusion: The frequency of ASCA was significantly higher in patients with CHC than in healthy controls.

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来源期刊

Arab Journal of Gastroenterology Medicine-Gastroenterology

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Arab Journal of Gastroenterology (AJG) publishes different studies related to the digestive system. It aims to be the foremost scientific peer reviewed journal encompassing diverse studies related to the digestive system and its disorders, and serving the Pan-Arab and wider community working on gastrointestinal disorders.