Jack Feron, Katrien Segaert, Foyzul Rahman, Sindre H Fosstveit, Kelsey E Joyce, Ahmed Gilani, Hilde Lohne-Seiler, Sveinung Berntsen, Karen J Mullinger, Samuel J E Lucas
{"title":"健康老年人脑血流量和动脉通过时间的决定因素。","authors":"Jack Feron, Katrien Segaert, Foyzul Rahman, Sindre H Fosstveit, Kelsey E Joyce, Ahmed Gilani, Hilde Lohne-Seiler, Sveinung Berntsen, Karen J Mullinger, Samuel J E Lucas","doi":"10.18632/aging.206112","DOIUrl":null,"url":null,"abstract":"<p><p>Cerebral blood flow (CBF) and arterial transit time (ATT), markers of brain vascular health, worsen with age. The primary aim of this cross-sectional study was to identify modifiable determinants of CBF and ATT in healthy older adults (<i>n</i> = 78, aged 60-81 years). Associations between cardiorespiratory fitness and CBF or ATT were of particular interest because the impact of cardiorespiratory fitness is not clear within existing literature. Secondly, this study assessed whether CBF or ATT relate to cognitive function in older adults. Multiple post-labelling delay pseudo-continuous arterial spin labelling estimated resting CBF and ATT in grey matter. Results from multiple linear regressions found higher BMI was associated with lower global CBF (β = -0.35, <i>P</i> = 0.008) and a longer global ATT (β = 0.30, <i>P</i> = 0.017), global ATT lengthened with increasing age (β = 0.43, <i>P</i> = 0.004), and higher cardiorespiratory fitness was associated with longer ATT in parietal (β = 0.44, <i>P</i> = 0.004) and occipital (β = 0.45, <i>P</i> = 0.003) regions. Global or regional CBF or ATT were not associated with processing speed, working memory, or attention. In conclusion, preventing excessive weight gain may help attenuate age-related declines in brain vascular health. ATT may be more sensitive to age-related decline than CBF, and therefore useful for early detection and management of cerebrovascular impairment. Finally, cardiorespiratory fitness appears to have little effect on CBF but may induce longer ATT in specific regions.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":null,"pages":null},"PeriodicalIF":3.9000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Determinants of cerebral blood flow and arterial transit time in healthy older adults.\",\"authors\":\"Jack Feron, Katrien Segaert, Foyzul Rahman, Sindre H Fosstveit, Kelsey E Joyce, Ahmed Gilani, Hilde Lohne-Seiler, Sveinung Berntsen, Karen J Mullinger, Samuel J E Lucas\",\"doi\":\"10.18632/aging.206112\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cerebral blood flow (CBF) and arterial transit time (ATT), markers of brain vascular health, worsen with age. The primary aim of this cross-sectional study was to identify modifiable determinants of CBF and ATT in healthy older adults (<i>n</i> = 78, aged 60-81 years). Associations between cardiorespiratory fitness and CBF or ATT were of particular interest because the impact of cardiorespiratory fitness is not clear within existing literature. Secondly, this study assessed whether CBF or ATT relate to cognitive function in older adults. Multiple post-labelling delay pseudo-continuous arterial spin labelling estimated resting CBF and ATT in grey matter. Results from multiple linear regressions found higher BMI was associated with lower global CBF (β = -0.35, <i>P</i> = 0.008) and a longer global ATT (β = 0.30, <i>P</i> = 0.017), global ATT lengthened with increasing age (β = 0.43, <i>P</i> = 0.004), and higher cardiorespiratory fitness was associated with longer ATT in parietal (β = 0.44, <i>P</i> = 0.004) and occipital (β = 0.45, <i>P</i> = 0.003) regions. Global or regional CBF or ATT were not associated with processing speed, working memory, or attention. In conclusion, preventing excessive weight gain may help attenuate age-related declines in brain vascular health. ATT may be more sensitive to age-related decline than CBF, and therefore useful for early detection and management of cerebrovascular impairment. Finally, cardiorespiratory fitness appears to have little effect on CBF but may induce longer ATT in specific regions.</p>\",\"PeriodicalId\":55547,\"journal\":{\"name\":\"Aging-Us\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2024-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aging-Us\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.18632/aging.206112\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging-Us","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18632/aging.206112","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
脑血流量(CBF)和动脉转运时间(ATT)是脑血管健康的标志,随着年龄的增长而恶化。这项横断面研究的主要目的是确定健康老年人(n = 78,年龄在 60-81 岁之间)的 CBF 和 ATT 的可调节决定因素。心肺功能与 CBF 或 ATT 之间的关联尤其引人关注,因为心肺功能的影响在现有文献中并不明确。其次,本研究评估了 CBF 或 ATT 是否与老年人的认知功能有关。多重标记后延迟伪连续动脉自旋标记估计了灰质中的静息 CBF 和 ATT。多重线性回归结果发现,体重指数越高,全局 CBF 越低(β = -0.35,P = 0.008),全局 ATT 越长(β = 0.30,P = 0.017)。43, P = 0.004),心肺功能越强,顶叶(β = 0.44, P = 0.004)和枕叶(β = 0.45, P = 0.003)区域的 ATT 越长。整体或区域 CBF 或 ATT 与处理速度、工作记忆或注意力无关。总之,防止体重过度增加可能有助于减轻与年龄相关的脑血管健康衰退。ATT 可能比 CBF 对年龄相关性衰退更敏感,因此有助于早期发现和管理脑血管损伤。最后,心肺功能似乎对CBF影响不大,但可能会在特定区域诱发更长的ATT。
Determinants of cerebral blood flow and arterial transit time in healthy older adults.
Cerebral blood flow (CBF) and arterial transit time (ATT), markers of brain vascular health, worsen with age. The primary aim of this cross-sectional study was to identify modifiable determinants of CBF and ATT in healthy older adults (n = 78, aged 60-81 years). Associations between cardiorespiratory fitness and CBF or ATT were of particular interest because the impact of cardiorespiratory fitness is not clear within existing literature. Secondly, this study assessed whether CBF or ATT relate to cognitive function in older adults. Multiple post-labelling delay pseudo-continuous arterial spin labelling estimated resting CBF and ATT in grey matter. Results from multiple linear regressions found higher BMI was associated with lower global CBF (β = -0.35, P = 0.008) and a longer global ATT (β = 0.30, P = 0.017), global ATT lengthened with increasing age (β = 0.43, P = 0.004), and higher cardiorespiratory fitness was associated with longer ATT in parietal (β = 0.44, P = 0.004) and occipital (β = 0.45, P = 0.003) regions. Global or regional CBF or ATT were not associated with processing speed, working memory, or attention. In conclusion, preventing excessive weight gain may help attenuate age-related declines in brain vascular health. ATT may be more sensitive to age-related decline than CBF, and therefore useful for early detection and management of cerebrovascular impairment. Finally, cardiorespiratory fitness appears to have little effect on CBF but may induce longer ATT in specific regions.