ABCB5 作为全转运体 ABCB5FL 和半转运体类 ABCB5β 的独特性。

IF 4.6 Q1 ONCOLOGY 癌症耐药(英文) Pub Date : 2024-08-07 eCollection Date: 2024-01-01 DOI:10.20517/cdr.2024.56
Louise Gerard, Jean-Pierre Gillet
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引用次数: 0

摘要

ABCB5 基因编码多种异构体,包括两种转运体(即 ABCB5FL 和 ABCB5β)和几种可溶性蛋白,如 ABCB5α,据推测它具有调节功能。ABCB5FL 是一种完全 ABC 转运体,在睾丸和前列腺中表达,而 ABCB5β 是一种非典型半转运体,其表达模式无处不在。研究表明,ABCB5β可标记几种癌症类型中的癌症干细胞。此外,ABCB5β和ABCB5FL还被证明在肿瘤发生和多药耐药性中发挥作用。然而,ABCB5β与ABCB5FL共享整个蛋白质序列,因此很难将它们区分开来。不能排除一种转运体的某些生物效应可能是由另一种异构体介导的。因此,很难解释现有的数据,关于它们在癌细胞中的功能仍存在一些争议。在这篇综述中,我们讨论了过去 20 年中收集到的有关 ABCB5 异构体的数据,并提出了一个共同点,在此基础上我们可以进一步揭示 ABCB5 转运体的病理生理作用。
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The uniqueness of ABCB5 as a full transporter ABCB5FL and a half-transporter-like ABCB5β.

The ABCB5 gene encodes several isoforms, including two transporters (i.e., ABCB5FL, ABCB5β) and several soluble proteins, such as ABCB5α which has been hypothesized to have a regulatory function. ABCB5FL is a full ABC transporter and is expressed in the testis and prostate, whereas ABCB5β is an atypical half-transporter with a ubiquitous expression pattern. ABCB5β has been shown to mark cancer stem cells in several cancer types. In addition, ABCB5β and ABCB5FL have been shown to play a role in tumorigenesis and multidrug resistance. However, ABCB5β shares its entire protein sequence with ABCB5FL, making them difficult to distinguish. It cannot be excluded that some biological effects described for one transporter may be mediated by the other isoform. Therefore, it is difficult to interpret the available data and some controversies remain regarding their function in cancer cells. In this review, we discuss the data collected on ABCB5 isoforms over the last 20 years and propose a common ground on which we can build further to unravel the pathophysiological roles of ABCB5 transporters.

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