膳食单萜与人类健康:挖掘治疗潜力。

IF 3.3 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimie Pub Date : 2025-01-01 DOI:10.1016/j.biochi.2024.09.002
Barbora Vyhlídalová , Karolína Ondrová , Iveta Zůvalová
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引用次数: 0

摘要

天然产品广泛应用于我们生活的各个方面--从家用清洁剂和食品生产,到化妆品和芳香疗法,再到替代医学和传统医学。我们的研究小组最近研究了几种单萜类化合物,它们通过异构靶向芳基烃受体(AhR),具有抗病毒和抗癌治疗的潜力。在实际应用之前,必须关注其对人体的生物效应。这篇综述文章主要探讨了 5 种单萜类化合物对人体健康的生物效应,这 5 种单萜类化合物之前被鉴定为 AhR 拮抗剂,具有作为抗病毒和抗癌药物的治疗潜力。我们全面阐述了它们的细胞毒性、抗炎、抗增殖和抗癌作用,以及与核受体的已知相互作用。正如已清楚表明的那样,单萜化合物总体上代表了一个几乎取之不尽、用之不竭的天然化合物宝库,具有影响、调节和改善人类健康的能力。
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Dietary monoterpenoids and human health: Unlocking the potential for therapeutic use
Natural products are widely used in different aspects of our lives – from household cleaners and food production, via cosmetics and aromatherapy, to both alternative and traditional medicine. In our research group, we have recently described several monoterpenoids with potential in the antiviral and anticancer therapy by allosteric targeting of aryl hydrocarbon receptor (AhR). Prior to any practical application, biological effects on human organism must be taken in concern. This review article is focused on the biological effects of 5 monoterpenoids on the human health previously identified as AhR antagonists with a therapeutic potential as antiviral and anticancer agents. We have thoroughly described cytotoxic, anti-inflammatory, anti-proliferative, and anticancer effects, as well as known interactions with nuclear receptors. As clearly demonstrated, monoterpenoids in general represent almost an inexhaustible reservoir of natural compounds possessing the ability to influence, modulate and improve human health.
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来源期刊
Biochimie
Biochimie 生物-生化与分子生物学
CiteScore
7.20
自引率
2.60%
发文量
219
审稿时长
40 days
期刊介绍: Biochimie publishes original research articles, short communications, review articles, graphical reviews, mini-reviews, and hypotheses in the broad areas of biology, including biochemistry, enzymology, molecular and cell biology, metabolic regulation, genetics, immunology, microbiology, structural biology, genomics, proteomics, and molecular mechanisms of disease. Biochimie publishes exclusively in English. Articles are subject to peer review, and must satisfy the requirements of originality, high scientific integrity and general interest to a broad range of readers. Submissions that are judged to be of sound scientific and technical quality but do not fully satisfy the requirements for publication in Biochimie may benefit from a transfer service to a more suitable journal within the same subject area.
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