口服地西他滨-西达脲苷治疗急性髓性白血病。

IF 3.8 2区医学 Q1 HEMATOLOGY British Journal of Haematology Pub Date : 2024-09-23 DOI:10.1111/bjh.19769

Ian M. Bouligny, Courtney D. DiNardo

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引用次数: 0

摘要

在一项涉及 89 名不符合强化化疗条件的急性髓性白血病患者的随机交叉研究中，Geissler 等人比较了静脉注射地西他滨和口服地西他滨-西达曲林。两种制剂的药代动力学和药效学相似。口服地西他滨-西达曲林的临床疗效与静脉注射地西他滨的历史数据一致。相关评论Geissler等人.急性髓性白血病口服地西他滨/卡佐尿苷与静脉注射地西他滨的比较：一项随机、交叉、注册、药代动力学研究。Doi: 10.1111/bjh.19741.

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Oral decitabine–cedazuridine in acute myeloid leukaemia

In a randomized crossover study involving 89 patients with acute myeloid leukaemia ineligible for intensive chemotherapy, Geissler et al. compared intravenous decitabine and oral decitabine–cedazuridine. The pharmacokinetics and pharmacodynamics of the two formulations were similar. The clinical efficacy of oral decitabine–cedazuridine was consistent with historical data of intravenous decitabine.

Commentary on: Geissler et al. Oral decitabine/cedazuridine versus intravenous decitabine for acute myeloid leukaemia: A randomised, crossover, registration, pharmacokinetics study. Br J Haematol 2024; 205:1734-1745.

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来源期刊

British Journal of Haematology 医学-血液学

CiteScore

8.60

自引率

4.60%

发文量

565

审稿时长

1 months

期刊介绍： The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.