钠-葡萄糖协同转运体 2 抑制剂对老年 2 型糖尿病患者的益处和安全性。

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes & Metabolism Journal Pub Date : 2024-09-01 Epub Date: 2024-09-12 DOI:10.4093/dmj.2024.0317
Ja Young Jeon, Dae Jung Kim
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引用次数: 0

摘要

与非糖尿病患者相比,2 型糖尿病患者患心血管疾病、心力衰竭、慢性肾病和过早死亡的风险更高。因此,治疗糖尿病的目的就是减少这些并发症。钠-葡萄糖协同转运体 2(SGLT2)抑制剂已显示出对心肾健康和代谢健康的有益影响,而不仅仅是控制血糖,这使其成为一类有望实现糖尿病治疗最终目标的药物。然而,尽管SGLT2抑制剂的益处已得到证实,但由于不良事件的报道,在符合条件的T2DM患者中使用SGLT2抑制剂的效果仍不理想。由于缺乏治疗经验和长期安全性数据不足,SGLT2 抑制剂在老年 T2DM 患者中的使用尤其有限。本文全面回顾了 SGLT2 抑制剂在老年 T2DM 患者中的风险-获益情况,并参考了有关心肾功能预后的前瞻性随机对照试验、原始研究、不同年龄组的亚组分析以及观察性队列研究的数据。
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Benefit and Safety of Sodium-Glucose Co-Transporter 2 Inhibitors in Older Patients with Type 2 Diabetes Mellitus.

People with type 2 diabetes mellitus (T2DM) are at higher risk of developing cardiovascular disease, heart failure, chronic kidney disease, and premature death than people without diabetes. Therefore, treatment of diabetes aims to reduce these complications. Sodium-glucose co-transporter 2 (SGLT2) inhibitors have shown beneficial effects on cardiorenal and metabolic health beyond glucose control, making them a promising class of drugs for achieving the ultimate goals of diabetes treatment. However, despite their proven benefits, the use of SGLT2 inhibitors in eligible patients with T2DM remains suboptimal due to reports of adverse events. The use of SGLT2 inhibitors is particularly limited in older patients with T2DM because of the lack of treatment experience and insufficient long-term safety data. This article comprehensively reviews the risk-benefit profile of SGLT2 inhibitors in older patients with T2DM, drawing on data from prospective randomized controlled trials of cardiorenal outcomes, original studies, subgroup analyses across different age groups, and observational cohort studies.

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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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