预测个人血糖反应的人体微生物组系统生物学。

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes & Metabolism Journal Pub Date : 2024-09-01 Epub Date: 2024-09-12 DOI:10.4093/dmj.2024.0382
Nikhil Kirtipal, Youngchang Seo, Jangwon Son, Sunjae Lee
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引用次数: 0

摘要

人们越来越认识到,人体肠道微生物群是糖尿病治疗的关键因素,在机体对治疗的反应中发挥着重要作用。然而,重要的是要知道,长期服用二甲双胍等药物和其他糖尿病治疗方法会导致问题、肠胃不适和肠道菌群失调。先进的测序技术提高了我们对肠道微生物组在糖尿病中作用的认识,揭示了微生物组成与代谢健康之间复杂的相互作用。我们通过研究各种组学数据,包括基因组学、转录组学、表观基因组学、蛋白质组学、代谢组学和元基因组学,探索肠道微生物群如何影响葡萄糖代谢和胰岛素敏感性。目前正在应用机器学习算法和基因组规模建模来寻找与糖尿病风险相关的微生物生物标志物、预测疾病进展并指导定制疗法。这项研究为专门的糖尿病治疗带来了希望。尽管取得了重大进展,但一些问题仍未得到解决,包括了解糖尿病病因与肠道微生物群之间的复杂关系,以及开发用户友好型技术创新。这篇微型综述探讨了多组学、精准医疗和机器学习之间的关系,以增进我们对肠道微生物组在糖尿病中的功能的了解。在精准医疗时代,最终目标是通过个性化治疗改善患者的预后。
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Systems Biology of Human Microbiome for the Prediction of Personal Glycaemic Response.

The human gut microbiota is increasingly recognized as a pivotal factor in diabetes management, playing a significant role in the body's response to treatment. However, it is important to understand that long-term usage of medicines like metformin and other diabetic treatments can result in problems, gastrointestinal discomfort, and dysbiosis of the gut flora. Advanced sequencing technologies have improved our understanding of the gut microbiome's role in diabetes, uncovering complex interactions between microbial composition and metabolic health. We explore how the gut microbiota affects glucose metabolism and insulin sensitivity by examining a variety of -omics data, including genomics, transcriptomics, epigenomics, proteomics, metabolomics, and metagenomics. Machine learning algorithms and genome-scale modeling are now being applied to find microbiological biomarkers associated with diabetes risk, predicted disease progression, and guide customized therapy. This study holds promise for specialized diabetic therapy. Despite significant advances, some concerns remain unanswered, including understanding the complex relationship between diabetes etiology and gut microbiota, as well as developing user-friendly technological innovations. This mini-review explores the relationship between multiomics, precision medicine, and machine learning to improve our understanding of the gut microbiome's function in diabetes. In the era of precision medicine, the ultimate goal is to improve patient outcomes through personalized treatments.

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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
期刊最新文献
Rbbp6-Mediated Bmal1 Ubiquitination Inhibits YAP1 Signaling Pathway to Promote Ferroptosis in Diabetes-Induced Testicular Damage. To Determine the Risk-Based Screening Interval for Diabetic Retinopathy: Development and Validation of Risk Algorithm from a Retrospective Cohort Study. Longitudinal Association of Changes in Metabolic Syndrome with Cognitive Function: 12-Year Follow-up of the Guangzhou Biobank Cohort Study. In Vivo Differentiation of Endogenous Bone Marrow-Derived Cells into Insulin-Producing Cells Using Four Soluble Factors. Use of Glucagon-Like Peptide-1 Receptor Agonists Does Not Increase the Risk of Cancer in Patients with Type 2 Diabetes Mellitus.
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