Ran Zhuo, Ramee L Younes, Kevin Ward, Shangxin Yang
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引用次数: 0
摘要
免疫力低下的患者容易反复发生弯曲杆菌感染。我们报告了一例布鲁顿 X 连锁丙种球蛋白血症患者因长期接受厄他培南治疗而反复感染空肠弯曲菌的病例。第五次复发的分离株产生了碳青霉烯耐药性，这与孔蛋白基因 porA 突变、启动子变化和染色体 blaOXA-61 基因重复有关。使用头孢吡肟和多西环素（后来改用莫西沙星）的联合疗法清除了感染。
Carbapenem resistant Campylobacter jejuni bacteremia in a Bruton's X-linked agammaglobulinemia patient.
Immunocompromised patients are prone to recurrent Campylobacter infections. We report a case of recurrent multi-drug resistant Campylobactor jejuni bloodstream infections in a Bruton's X-linked agammaglobulinemia patient with prolonged ertapenem treatment. The isolate from the fifth recurrence developed carbapenem resistance, which is associated with mutations in a porin gene porA, and promoter changes and duplication of chromosomal blaOXA-61 gene. Combination therapy using cefepime and doxycycline (later switched to moxifloxacin) cleared the infection.
期刊介绍：
EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.
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