澳大利亚男同性恋、双性恋和非二元性行为者对强力霉素预防的接受程度、之前的抗生素使用情况以及对抗菌素耐药性的了解。

IF 2.4 4区 医学 Q3 INFECTIOUS DISEASES Sexually transmitted diseases Pub Date : 2024-09-24 DOI:10.1097/OLQ.0000000000002079
Martin Holt, Benjamin R Bavinton, Sarah K Calabrese, Timothy R Broady, Shawn Clackett, Vincent J Cornelisse, Simin Yu, Tina Gordon, Dash Heath-Paynter, John B F de Wit, James MacGibbon
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引用次数: 0

摘要

背景:人们对包括强力霉素暴露后预防(doxy-PEP)在内的新型性传播感染(STI)预防策略越来越感兴趣。我们评估了澳大利亚男同性恋、双性恋和非二元性行为者对强力霉素暴露后预防疗法和其他性传播感染预防策略的兴趣,以及以前使用抗生素预防性传播感染的情况和对抗菌素耐药性(AMR)的了解情况:我们于 2023 年 6 月至 7 月进行了一次全国性在线调查。方法:我们于 2023 年 6 月至 7 月进行了一次全国性的在线调查,采用多变量逻辑回归来确定与强力PEP可接受性相关的因素:在 2046 名参与者中,26.9% 的人在过去一年中被诊断出患有性传播疾病。45.1%的样本认为安全套是可接受的性传播感染预防策略,54.0%的样本认为性传播感染暴露前预防是可接受的策略,75.8%的样本认为强力PEP是可接受的策略。7.5%的样本称曾使用抗生素预防性传播疾病,2.6%的样本称目前正在使用抗生素预防性传播疾病。超过一半的样本(62.1%)对 AMR 有一定的了解。在对 AMR 有所了解的样本中,76.2% 的人对此表示担忧。对使用强力PEP的兴趣与之前使用抗生素预防性传播疾病的情况有独立关联(调整后的几率比3.09,95%CI = 1.78-5.35,p < 0.001),而对AMR感到担忧的人对强力PEP的兴趣较低(AOR 0.51,95%CI = 0.36-0.72,p < 0.001):结论:澳大利亚的男同性恋者、双性恋者和非二元人群对Doxy-PEP的接受度很高,很少有因素能区分是否有兴趣使用它。我们建议社区和专业人士就如何有效使用强力杀菌剂-PEP、AMR 以及强力杀菌剂-PEP 的最大受益者等问题开展讨论和教育。
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Acceptability of doxycycline prophylaxis, prior antibiotic use, and knowledge of antimicrobial resistance among Australian gay and bisexual men and non-binary people.

Background: There is growing interest in novel sexually transmissible infection (STI) prevention strategies, including doxycycline post-exposure prophylaxis (doxy-PEP). We assessed interest in doxy-PEP and other STI prevention strategies among gay and bisexual men and non-binary people in Australia, as well as prior antibiotic use for STI prevention, and knowledge of antimicrobial resistance (AMR).

Methods: We conducted a national, online survey in June-July 2023. Multivariable logistic regression was used to identify factors associated with the acceptability of doxy-PEP.

Results: Of 2,046 participants, 26.9% had been diagnosed with an STI in the previous year. Condoms were rated as an acceptable STI prevention strategy by 45.1% of the sample, STI pre-exposure prophylaxis by 54.0%, and doxy-PEP by 75.8%. Previous antibiotic use for STI prevention was reported by 7.5% of the sample, and 2.6% were currently using antibiotics for STI prevention. Over half the sample (62.1%) had some knowledge of AMR. Of those who knew something about AMR,76.2% were concerned about it. Interest in using doxy-PEP was independently associated with previous use of antibiotics for STI prevention (adjusted odds ratio 3.09, 95%CI = 1.78-5.35, p < 0.001), while those who were concerned about AMR were less interested in it (AOR 0.51, 95%CI = 0.36-0.72, p < 0.001).

Conclusions: Doxy-PEP was highly acceptable to gay and bisexual men and non-binary people in Australia, and few factors distinguished between interest in using it or not. We recommend community and professional discussion and education about the effective use of doxy-PEP, AMR, and who would most benefit from doxy-PEP.

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来源期刊
Sexually transmitted diseases
Sexually transmitted diseases 医学-传染病学
CiteScore
4.00
自引率
16.10%
发文量
289
审稿时长
3-8 weeks
期刊介绍: ​Sexually Transmitted Diseases, the official journal of the American Sexually Transmitted Diseases Association​, publishes peer-reviewed, original articles on clinical, laboratory, immunologic, epidemiologic, behavioral, public health, and historical topics pertaining to sexually transmitted diseases and related fields. Reports from the CDC and NIH provide up-to-the-minute information. A highly respected editorial board is composed of prominent scientists who are leaders in this rapidly changing field. Included in each issue are studies and developments from around the world.
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