Raylene A Reimer , Stephan Theis , Yoghatama Cindya Zanzer
{"title":"补充菊苣菊粉型果聚糖对体重管理结果的影响：随机对照试验的系统回顾、荟萃分析和荟萃回归。","authors":"Raylene A Reimer , Stephan Theis , Yoghatama Cindya Zanzer","doi":"10.1016/j.ajcnut.2024.09.019","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Excess body weight and adiposity can adversely affect metabolic health. Prebiotics such as inulin-type fructans (ITFs) from chicory root are known to modulate gut microbiota and may improve body weight regulation.</div></div><div><h3>Objectives</h3><div>This study aimed to assess evidence for chicory ITF supplementation to support weight management.</div></div><div><h3>Methods</h3><div>Eligible articles (initial search to 2021, updated to February 2023) were searched from EMBASE, MEDLINE (PubMed), and Cochrane Library. Data on primary (body weight) and secondary outcomes [body mass index (BMI), total fat mass, body fat percentage, and waist circumference] were extracted by 2 reviewers independently. Random-effects model using inverse-variance method was used. Subgroup analysis (health status and ITF type) and meta-regression (dose and duration) were evaluated.</div></div><div><h3>Results</h3><div>A total of 32 eligible studies were included. Chicory ITF significantly reduced body weight [mean difference (MD): −0.97 kg; 95% CI: −1.34, −0.59); <em>n</em> = 1184] compared with placebo. ITF favored overall effects reduction in BMI (MD: −0.39 kg/m<sup>2</sup>; 95% CI: −0.57, −0.20; <em>n</em> = 985), fat mass (MD: −0.37 kg; 95% CI: −0.61, −0.13; <em>n</em> = 397), waist circumference (MD: −1.03 cm; 95% CI: −1.69, −0.37; <em>n</em> = 604), and for intervention duration of >8 wk, body fat percentage (MD: −0.78%; 95% CI: −1.17, −0.39; <em>n</em> = 488). Except for considerable heterogeneity in body weight (<em>I</em><sup>2</sup>: 73%) and body fat percentage (<em>I</em><sup>2</sup>: 75%), all other outcomes had negligible to moderate heterogeneity. Significant reduction in body weight, BMI, and waist circumference was evident irrespective of participants' health status. There was minimal evidence that dose, duration, or type of ITF influenced the magnitude of reductions in outcomes.</div></div><div><h3>Conclusions</h3><div>Chicory ITF supplementation may benefit weight management by reducing body weight, BMI, fat mass, waist circumference, and, to a certain extent, body fat percentage.</div><div>This systematic review with meta-analysis was registered at PROSPERO as CRD42020184908.</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"120 5","pages":"Pages 1245-1258"},"PeriodicalIF":6.9000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effects of chicory inulin-type fructans supplementation on weight management outcomes: systematic review, meta-analysis, and meta-regression of randomized controlled trials\",\"authors\":\"Raylene A Reimer , Stephan Theis , Yoghatama Cindya Zanzer\",\"doi\":\"10.1016/j.ajcnut.2024.09.019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Excess body weight and adiposity can adversely affect metabolic health. Prebiotics such as inulin-type fructans (ITFs) from chicory root are known to modulate gut microbiota and may improve body weight regulation.</div></div><div><h3>Objectives</h3><div>This study aimed to assess evidence for chicory ITF supplementation to support weight management.</div></div><div><h3>Methods</h3><div>Eligible articles (initial search to 2021, updated to February 2023) were searched from EMBASE, MEDLINE (PubMed), and Cochrane Library. Data on primary (body weight) and secondary outcomes [body mass index (BMI), total fat mass, body fat percentage, and waist circumference] were extracted by 2 reviewers independently. Random-effects model using inverse-variance method was used. Subgroup analysis (health status and ITF type) and meta-regression (dose and duration) were evaluated.</div></div><div><h3>Results</h3><div>A total of 32 eligible studies were included. Chicory ITF significantly reduced body weight [mean difference (MD): −0.97 kg; 95% CI: −1.34, −0.59); <em>n</em> = 1184] compared with placebo. ITF favored overall effects reduction in BMI (MD: −0.39 kg/m<sup>2</sup>; 95% CI: −0.57, −0.20; <em>n</em> = 985), fat mass (MD: −0.37 kg; 95% CI: −0.61, −0.13; <em>n</em> = 397), waist circumference (MD: −1.03 cm; 95% CI: −1.69, −0.37; <em>n</em> = 604), and for intervention duration of >8 wk, body fat percentage (MD: −0.78%; 95% CI: −1.17, −0.39; <em>n</em> = 488). Except for considerable heterogeneity in body weight (<em>I</em><sup>2</sup>: 73%) and body fat percentage (<em>I</em><sup>2</sup>: 75%), all other outcomes had negligible to moderate heterogeneity. Significant reduction in body weight, BMI, and waist circumference was evident irrespective of participants' health status. There was minimal evidence that dose, duration, or type of ITF influenced the magnitude of reductions in outcomes.</div></div><div><h3>Conclusions</h3><div>Chicory ITF supplementation may benefit weight management by reducing body weight, BMI, fat mass, waist circumference, and, to a certain extent, body fat percentage.</div><div>This systematic review with meta-analysis was registered at PROSPERO as CRD42020184908.</div></div>\",\"PeriodicalId\":50813,\"journal\":{\"name\":\"American Journal of Clinical Nutrition\",\"volume\":\"120 5\",\"pages\":\"Pages 1245-1258\"},\"PeriodicalIF\":6.9000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Clinical Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0002916524007512\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/9/21 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Clinical Nutrition","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0002916524007512","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/21 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
The effects of chicory inulin-type fructans supplementation on weight management outcomes: systematic review, meta-analysis, and meta-regression of randomized controlled trials
Background
Excess body weight and adiposity can adversely affect metabolic health. Prebiotics such as inulin-type fructans (ITFs) from chicory root are known to modulate gut microbiota and may improve body weight regulation.
Objectives
This study aimed to assess evidence for chicory ITF supplementation to support weight management.
Methods
Eligible articles (initial search to 2021, updated to February 2023) were searched from EMBASE, MEDLINE (PubMed), and Cochrane Library. Data on primary (body weight) and secondary outcomes [body mass index (BMI), total fat mass, body fat percentage, and waist circumference] were extracted by 2 reviewers independently. Random-effects model using inverse-variance method was used. Subgroup analysis (health status and ITF type) and meta-regression (dose and duration) were evaluated.
Results
A total of 32 eligible studies were included. Chicory ITF significantly reduced body weight [mean difference (MD): −0.97 kg; 95% CI: −1.34, −0.59); n = 1184] compared with placebo. ITF favored overall effects reduction in BMI (MD: −0.39 kg/m2; 95% CI: −0.57, −0.20; n = 985), fat mass (MD: −0.37 kg; 95% CI: −0.61, −0.13; n = 397), waist circumference (MD: −1.03 cm; 95% CI: −1.69, −0.37; n = 604), and for intervention duration of >8 wk, body fat percentage (MD: −0.78%; 95% CI: −1.17, −0.39; n = 488). Except for considerable heterogeneity in body weight (I2: 73%) and body fat percentage (I2: 75%), all other outcomes had negligible to moderate heterogeneity. Significant reduction in body weight, BMI, and waist circumference was evident irrespective of participants' health status. There was minimal evidence that dose, duration, or type of ITF influenced the magnitude of reductions in outcomes.
Conclusions
Chicory ITF supplementation may benefit weight management by reducing body weight, BMI, fat mass, waist circumference, and, to a certain extent, body fat percentage.
This systematic review with meta-analysis was registered at PROSPERO as CRD42020184908.
期刊介绍：
American Journal of Clinical Nutrition is recognized as the most highly rated peer-reviewed, primary research journal in nutrition and dietetics.It focuses on publishing the latest research on various topics in nutrition, including but not limited to obesity, vitamins and minerals, nutrition and disease, and energy metabolism.
Purpose:
The purpose of AJCN is to:
Publish original research studies relevant to human and clinical nutrition.
Consider well-controlled clinical studies describing scientific mechanisms, efficacy, and safety of dietary interventions in the context of disease prevention or health benefits.
Encourage public health and epidemiologic studies relevant to human nutrition.
Promote innovative investigations of nutritional questions employing epigenetic, genomic, proteomic, and metabolomic approaches.
Include solicited editorials, book reviews, solicited or unsolicited review articles, invited controversy position papers, and letters to the Editor related to prior AJCN articles.
Peer Review Process:
All submitted material with scientific content undergoes peer review by the Editors or their designees before acceptance for publication.
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