[阿苯达唑引起的肝毒性:治疗棘球蚴病的安全替代方案]。

Innere Medizin (Heidelberg, Germany) Pub Date : 2025-02-01 Epub Date: 2024-09-23 DOI:10.1007/s00108-024-01796-y
Laura Muana Wilhelm, Joschka Bachmann, Markus Cornberg, Heiner Wedemeyer, Bernd Heinrich
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引用次数: 0

摘要

感染多棘球蚴会导致肺泡棘球蚴病的临床表现。其特征是形成肺泡状肝肿瘤,通常在病程中坏死。形成假性囊肿。特别是在早期阶段,建议进行根治性切除,然后用阿苯达唑进行长期治疗。然而,大多数患者无法接受根治性手术。在这种情况下,阿苯达唑疗法是首选治疗方法。我们介绍了一例罕见的阿苯达唑相关性肝炎病例,患者感染了无法手术的多角棘球蚴,在改用甲苯达唑治疗后取得了良好的疗效。
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[Hepatotoxicity due to albendazole: safe alternatives for echinococcosis therapy].

Infection with Echinococcus multilocularis leads to the clinical manifestation of alveolar echinococcosis. This is characterized by the formation of alveolar liver tumours, which usually disintegrate necrotically in the course of the disease. Pseudocysts are formed. Especially in the early stages, curative resection followed by long-term treatment with albendazole is recommended. However, the majority of patients are not amenable to curative surgery. In these cases, albendazole therapy is the first-choice treatment. We present a rare case of albendazole-associated hepatitis in a patient with inoperable Echinococcus multilocularis infection, with a favourable outcome following a change in treatment to mebendazole.

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