{"title":"了解躁郁症患者童年受虐与情感症状之间的关系:网络分析的新见解","authors":"","doi":"10.1016/j.psychres.2024.116197","DOIUrl":null,"url":null,"abstract":"<div><div>The impact of childhood abuse on the presentation of bipolar disorder could be further elucidated by comparing the networks of affective symptoms among individuals with and with no history of childhood abuse. Data from 476 participants in the Clinical Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder study were used to fit several regularised Gaussian Graphical Models. Differences in the presentation of depressive and manic symptoms were uncovered: only among participants with a history of childhood abuse, <em>inadequacy</em> and <em>pessimism</em> were central symptoms in the network of depressive symptoms, while <em>racing thoughts</em> was an important symptom in the network of manic symptoms. Following network theory, focusing treatments at the symptom-level and on central symptoms – like <em>inadequacy, pessimism</em>, and <em>racing thoughts</em> – could be an effective approach for managing affective symptoms among the sizeable proportion of people with bipolar disorder who have experienced childhood abuse. This study contributes a thorough investigation of the networks of affective symptoms among participants with and with no history of childhood abuse, albeit limited by the use of a binary, self-report measure of childhood abuse, thereby emphasising the importance of assessing for childhood abuse and taking needed steps towards identifying novel targets for treating bipolar disorder.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165178124004827/pdfft?md5=fa9a5926712aae207d277d3ddf14cf2b&pid=1-s2.0-S0165178124004827-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Understanding the relationship between childhood abuse and affective symptoms in bipolar disorder: New insights from a network analysis\",\"authors\":\"\",\"doi\":\"10.1016/j.psychres.2024.116197\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The impact of childhood abuse on the presentation of bipolar disorder could be further elucidated by comparing the networks of affective symptoms among individuals with and with no history of childhood abuse. Data from 476 participants in the Clinical Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder study were used to fit several regularised Gaussian Graphical Models. Differences in the presentation of depressive and manic symptoms were uncovered: only among participants with a history of childhood abuse, <em>inadequacy</em> and <em>pessimism</em> were central symptoms in the network of depressive symptoms, while <em>racing thoughts</em> was an important symptom in the network of manic symptoms. Following network theory, focusing treatments at the symptom-level and on central symptoms – like <em>inadequacy, pessimism</em>, and <em>racing thoughts</em> – could be an effective approach for managing affective symptoms among the sizeable proportion of people with bipolar disorder who have experienced childhood abuse. This study contributes a thorough investigation of the networks of affective symptoms among participants with and with no history of childhood abuse, albeit limited by the use of a binary, self-report measure of childhood abuse, thereby emphasising the importance of assessing for childhood abuse and taking needed steps towards identifying novel targets for treating bipolar disorder.</div></div>\",\"PeriodicalId\":20819,\"journal\":{\"name\":\"Psychiatry Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0165178124004827/pdfft?md5=fa9a5926712aae207d277d3ddf14cf2b&pid=1-s2.0-S0165178124004827-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychiatry Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165178124004827\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatry Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165178124004827","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0
摘要
通过比较有童年虐待史和没有童年虐待史的人的情感症状网络,可以进一步阐明童年虐待对躁狂症表现的影响。我们利用 "双相情感障碍临床疗效比较研究"(Clinical Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder)中476名参与者的数据拟合了几个正则化高斯图形模型。结果发现,抑郁症状和躁狂症状的表现形式存在差异:只有在有童年虐待史的参与者中,不足和悲观才是抑郁症状网络中的核心症状,而思维奔逸则是躁狂症状网络中的重要症状。根据网络理论,将治疗重点放在症状层面和中心症状上(如不足、悲观和思维奔逸),可能是一种有效的方法,可以控制相当一部分曾在童年遭受虐待的躁郁症患者的情感症状。这项研究对有童年受虐史和无童年受虐史的参与者的情感症状网络进行了深入调查,尽管由于使用了二元自我报告童年受虐情况的测量方法而受到了限制,但这项研究还是做出了贡献,从而强调了评估童年受虐情况的重要性,并为确定治疗躁郁症的新目标迈出了必要的步伐。
Understanding the relationship between childhood abuse and affective symptoms in bipolar disorder: New insights from a network analysis
The impact of childhood abuse on the presentation of bipolar disorder could be further elucidated by comparing the networks of affective symptoms among individuals with and with no history of childhood abuse. Data from 476 participants in the Clinical Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder study were used to fit several regularised Gaussian Graphical Models. Differences in the presentation of depressive and manic symptoms were uncovered: only among participants with a history of childhood abuse, inadequacy and pessimism were central symptoms in the network of depressive symptoms, while racing thoughts was an important symptom in the network of manic symptoms. Following network theory, focusing treatments at the symptom-level and on central symptoms – like inadequacy, pessimism, and racing thoughts – could be an effective approach for managing affective symptoms among the sizeable proportion of people with bipolar disorder who have experienced childhood abuse. This study contributes a thorough investigation of the networks of affective symptoms among participants with and with no history of childhood abuse, albeit limited by the use of a binary, self-report measure of childhood abuse, thereby emphasising the importance of assessing for childhood abuse and taking needed steps towards identifying novel targets for treating bipolar disorder.
期刊介绍:
Psychiatry Research offers swift publication of comprehensive research reports and reviews within the field of psychiatry.
The scope of the journal encompasses:
Biochemical, physiological, neuroanatomic, genetic, neurocognitive, and psychosocial determinants of psychiatric disorders.
Diagnostic assessments of psychiatric disorders.
Evaluations that pursue hypotheses about the cause or causes of psychiatric diseases.
Evaluations of pharmacologic and non-pharmacologic psychiatric treatments.
Basic neuroscience studies related to animal or neurochemical models for psychiatric disorders.
Methodological advances, such as instrumentation, clinical scales, and assays directly applicable to psychiatric research.