Yi Yang, Ning Ding, Xinyao Du, Daqian Gao, Debora Puglia, Fengning Wang, Xiao Yang, Fei Xu, Weijun Yang
{"title":"将维生素 B 接枝到木质素上,生产用于伤口敷料水凝胶的高生物活性材料","authors":"Yi Yang, Ning Ding, Xinyao Du, Daqian Gao, Debora Puglia, Fengning Wang, Xiao Yang, Fei Xu, Weijun Yang","doi":"10.1021/acssuschemeng.4c05891","DOIUrl":null,"url":null,"abstract":"The low radical scavenging activity (RSA) and antibacterial efficiency of lignin limit its applications as a value-added bioactive material. In order to produce greener lignin-based bioactive agents, in this work, vitamin B1 (VB1) was grafted onto lignin nanoparticles (LNPs) through a simple Mannich reaction. The structure and bioactivities of LNP-VB were then studied, and the antimicrobial rates of LNP-30VB against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> reached 98 and 90%, respectively, increasing by 172 and 291% compared to that of LNPs. Meanwhile, the RSA of LNP-VB was measured by DPPH and HUVEC methods, and the RSA of LNP-30VB was enhanced from 71.9% (LNP) up to 82.4%. Therefore, the RSA and antibacterial activities of LNP-VB were simultaneously and greatly improved, and their mechanisms were also elucidated, which mainly depends on the structure evolution, such as more phenoxyl radicals and H<sup>+</sup> can be dissociated from lignin phenol hydroxyl, and new forming tertiary amines will also affect the microbial physiological activity. Based on excellent bioactivities, LNP-VB was then utilized for the preparation of wound dressing hydrogels, and faster wound healing and less inflammation effects can be achieved. Meanwhile, the granulation tissue and re-epithelialization phenotype can also be observed at the edge of the wound when analyzed via H&E staining.","PeriodicalId":25,"journal":{"name":"ACS Sustainable Chemistry & Engineering","volume":null,"pages":null},"PeriodicalIF":7.1000,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Grafting Vitamin B onto Lignin to Produce Highly Bioactive Materials for Wound Dressing Hydrogels\",\"authors\":\"Yi Yang, Ning Ding, Xinyao Du, Daqian Gao, Debora Puglia, Fengning Wang, Xiao Yang, Fei Xu, Weijun Yang\",\"doi\":\"10.1021/acssuschemeng.4c05891\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The low radical scavenging activity (RSA) and antibacterial efficiency of lignin limit its applications as a value-added bioactive material. In order to produce greener lignin-based bioactive agents, in this work, vitamin B1 (VB1) was grafted onto lignin nanoparticles (LNPs) through a simple Mannich reaction. The structure and bioactivities of LNP-VB were then studied, and the antimicrobial rates of LNP-30VB against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> reached 98 and 90%, respectively, increasing by 172 and 291% compared to that of LNPs. Meanwhile, the RSA of LNP-VB was measured by DPPH and HUVEC methods, and the RSA of LNP-30VB was enhanced from 71.9% (LNP) up to 82.4%. Therefore, the RSA and antibacterial activities of LNP-VB were simultaneously and greatly improved, and their mechanisms were also elucidated, which mainly depends on the structure evolution, such as more phenoxyl radicals and H<sup>+</sup> can be dissociated from lignin phenol hydroxyl, and new forming tertiary amines will also affect the microbial physiological activity. Based on excellent bioactivities, LNP-VB was then utilized for the preparation of wound dressing hydrogels, and faster wound healing and less inflammation effects can be achieved. Meanwhile, the granulation tissue and re-epithelialization phenotype can also be observed at the edge of the wound when analyzed via H&E staining.\",\"PeriodicalId\":25,\"journal\":{\"name\":\"ACS Sustainable Chemistry & Engineering\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.1000,\"publicationDate\":\"2024-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Sustainable Chemistry & Engineering\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1021/acssuschemeng.4c05891\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Sustainable Chemistry & Engineering","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acssuschemeng.4c05891","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Grafting Vitamin B onto Lignin to Produce Highly Bioactive Materials for Wound Dressing Hydrogels
The low radical scavenging activity (RSA) and antibacterial efficiency of lignin limit its applications as a value-added bioactive material. In order to produce greener lignin-based bioactive agents, in this work, vitamin B1 (VB1) was grafted onto lignin nanoparticles (LNPs) through a simple Mannich reaction. The structure and bioactivities of LNP-VB were then studied, and the antimicrobial rates of LNP-30VB against Escherichia coli and Staphylococcus aureus reached 98 and 90%, respectively, increasing by 172 and 291% compared to that of LNPs. Meanwhile, the RSA of LNP-VB was measured by DPPH and HUVEC methods, and the RSA of LNP-30VB was enhanced from 71.9% (LNP) up to 82.4%. Therefore, the RSA and antibacterial activities of LNP-VB were simultaneously and greatly improved, and their mechanisms were also elucidated, which mainly depends on the structure evolution, such as more phenoxyl radicals and H+ can be dissociated from lignin phenol hydroxyl, and new forming tertiary amines will also affect the microbial physiological activity. Based on excellent bioactivities, LNP-VB was then utilized for the preparation of wound dressing hydrogels, and faster wound healing and less inflammation effects can be achieved. Meanwhile, the granulation tissue and re-epithelialization phenotype can also be observed at the edge of the wound when analyzed via H&E staining.
期刊介绍:
ACS Sustainable Chemistry & Engineering is a prestigious weekly peer-reviewed scientific journal published by the American Chemical Society. Dedicated to advancing the principles of green chemistry and green engineering, it covers a wide array of research topics including green chemistry, green engineering, biomass, alternative energy, and life cycle assessment.
The journal welcomes submissions in various formats, including Letters, Articles, Features, and Perspectives (Reviews), that address the challenges of sustainability in the chemical enterprise and contribute to the advancement of sustainable practices. Join us in shaping the future of sustainable chemistry and engineering.