具有增强过氧化物酶样活性的腺苷三磷酸酶协同钴金属有机框架,用于检测 L-胱氨酸

IF 2.7 3区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Inorganica Chimica Acta Pub Date : 2024-09-21 DOI:10.1016/j.ica.2024.122375
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引用次数: 0

摘要

金属有机框架(MOFs)在类酶材料领域发挥着重要作用,并已成功应用于各种过氧化物酶类研究,包括底物 3,3′,5,5′-四甲基联苯胺(TMB)的催化氧化。然而,MOFs 在水环境中有限的化学稳定性阻碍了它们的催化应用。为了解决这一固有缺陷并增强 MOFs 的过氧化物酶样活性,有人提出了一种涉及三磷酸腺苷(ATP)键合的方法。在这项研究中,由钴 MOFs(Co-MOFs)和 ATP 组成的合作材料被用作 TMB 催化的模型催化剂。在 pH 值为 3 至 9、温度为 25 至 60 ℃ 的条件下,ATP 的存在大大提高了 Co-MOFs 的催化能力。值得注意的是,在 pH 值为 7 和温度为 60 ℃ 的条件下,催化效率分别提高了约 100 倍和 4600% 。这种类似过氧化物酶的催化系统提供了一种比色检测方法,可选择性地检测 L-半胱氨酸,检测限低至 76.2 nM。将 ATP 加入 Co-MOFs 为利用 MOFs 进行催化提供了一种方便、直接和温和的新方法。
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Adenosine triphosphatase synergetic cobalt metal-organic frameworks with enhanced peroxidase-like activity for L-cystine detection
The role of metal–organic frameworks (MOFs) in the field of enzyme-like materials is significant, and they have been successfully applied to various peroxidase-like studies involving catalytic oxidation of the substrate 3,3′,5,5′-tetramethylbenzidine (TMB). However, the limited chemical stability of MOFs in aqueous environments hampers their catalytic applications. To address this inherent drawback and enhance the peroxidase-like activity of MOFs, a method involving adenosine triphosphate (ATP) bonding was proposed. In this study, collaborative materials comprising cobalt MOFs (Co-MOFs) and ATP were utilized as model catalysts for TMB catalysis. The presence of ATP significantly improved the catalytic capability of Co-MOFs over a pH range from 3 to 9 and temperatures ranging from 25 to 60 °C. Notably, at pH 7 and 60 °C, the catalytic efficiency increased by approximately 100 times and an impressive enhancement rate of up to 4600% was achieved respectively. This peroxidase-like catalytic system offers a colorimetric detection assay that selectively detects L-cysteine with a limit of detection as low as 76.2 nM. Incorporating ATP into Co-MOFs presents a novel approach for utilizing MOFs in catalysis that is convenient, straightforward, and gentle.
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来源期刊
Inorganica Chimica Acta
Inorganica Chimica Acta 化学-无机化学与核化学
CiteScore
6.00
自引率
3.60%
发文量
440
审稿时长
35 days
期刊介绍: Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.
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