Glasesterterpenoids A-C：从 Lindera glauca 根部分离出的三种具有 7-环己基十氢萘碳骨架的酯类化合物

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Chinese Journal of Natural Medicines Pub Date : 2024-09-01 DOI:10.1016/S1875-5364(24)60657-6

Shiting HE , Qinghui ZOU , Qi ZHANG , Yingming LUO , Die YAN , Jingxin HE , Yena LIU , Hui CUI

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引用次数: 0

摘要

从 Lindera glauca（林达草）的根中分离出了三种新的酯类化合物 glasesterterpenoids A-C（1-3），它们具有前所未有的 7-Cyclohexyldecahydronaphthalene 碳骨架。通过量子化学计算和光谱方法阐明了它们的结构。提出了 1-3 的生物发生途径。在生物测定中，与阳性对照喜树碱相比，glasesterpenoid C 具有 DNA 拓扑异构酶 1（Top1）抑制活性。这些发现代表了从鳞茎草根中首次发现具有 7-环己基十氢萘碳骨架的酯类化合物。

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Glasesterterpenoids A−C: three sesterterpenoids with 7-cyclohexyldecahydronaphthalene carbon skeleton isolated from the root of Lindera glauca

Three novel sesterterpenoids glasesterterpenoids A−C (1−3), featuring an unprecedented 7-cyclohexyldecahydronaphthalene carbon skeleton, were isolated from the root of Lindera glauca (L. glauca). Their structures were elucidated by quantum chemical calculations and spectroscopic methods. The biogenetic pathway for 1−3 is proposed. In the bioassay, glasesterterpenoid C exhibited DNA topoisomerase 1 (Top1) inhibitory activity compared with the positive control, camptothecin. These findings represent the first examples of sesterterpenoids with a 7-cyclohexyldecahydronaphthalene carbon skeleton from the root of L. glauca.

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来源期刊

Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.50

自引率

4.30%

发文量

2235

期刊介绍： The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.