Marcin Warminski, Katarzyna Grab, Kacper Szczepanski, Tomasz Spiewla, Joanna Zuberek, Joanna Kowalska, Jacek Jemielity
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Photoactivatable mRNA 5′ Cap Analogs for RNA-Protein Crosslinking (Adv. Sci. 36/2024)
mRNA Cap Photoaffinity Labeling Probes
Chemically modified messenger RNA (mRNA) has been demonstrated to be a valuable therapeutic platform for antiviral vaccines. However, a more comprehensive understanding of its translation mechanisms is essential for the development of more effective therapeutics. The cover image depicts a translation initiation factor 4E in complex with an mRNA 5′ cap structure, which was modified by Marcin Warminski and co-workers to create novel molecular tools for the identification of binders of different mRNA 5′-end variants. More details can be found in article number 2400994.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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