消耗 Rho GTP 酶 Cdc42、Rac1 或 RhoA 可减少 PDGF 诱导的 STAT1 和 STAT3 信号传导

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry and Biophysics Reports Pub Date : 2024-09-25 DOI:10.1016/j.bbrep.2024.101828

Erik Wåhlén, Johan Lennartsson , Johan Heldin

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引用次数: 0

摘要

本研究探讨了 Rho GTPases（特别是 Cdc42、Rac1 和 RhoA）在血小板衍生生长因子受体（PDGFRα 和 PDGFRβ）信号传导中的作用。信号转导和激活转录（STAT）蛋白是细胞增殖和免疫反应等过程所必需的，它们在 PDGFR 的下游被激活。这些通路的失调与包括癌症在内的各种疾病有关。目前的研究探讨了 Rho GTPase 缺失对 PDGFR 磷酸化、STAT 蛋白稳定性和下游信号转导的影响。结果表明，消耗 Cdc42、Rac1 或 RhoA 会损害 PDGFR 磷酸化并减少 STAT1 和 STAT3 信号传导，但不会显著影响 AKT 和 ERK1/2 通路。这些发现突显了 Rho GTPases 在 PDGFR 介导的 STAT 信号转导中的关键调节作用。

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Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling

This study investigates the role of Rho GTPases, specifically Cdc42, Rac1, and RhoA, in platelet-derived growth factor receptors (PDGFRα and PDGFRβ) signaling. Signal transducer and activator of transcription (STAT) proteins, essential for cellular processes such as proliferation and immune response, are activated downstream of PDGFRs. Dysregulation of these pathways is linked to various diseases, including cancer. The current study examines the effects of Rho GTPase depletion on PDGFR phosphorylation, STAT protein stability, and downstream signaling. Results indicate that depletion of Cdc42, Rac1, or RhoA impairs PDGFR phosphorylation and reduces STAT1 and STAT3 signaling, without significantly affecting AKT and ERK1/2 pathways. The findings highlight the critical regulatory roles of Rho GTPases in PDGFR-mediated STAT signaling.

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.