压力过大:子宫收缩力如何影响子宫肌瘤的发展,叙述性综述

Megan R. Sax M.D. , Carolyn Nietupski B.S. , Rachel E. Warwar M.D. , Andreja Moset Zupan B.S. , Emily G. Hurley M.D. , Stacey C. Schutte Ph.D.
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引用次数: 0

摘要

子宫肌瘤因每月例行的子宫收缩而承受巨大的机械力,而且还发现交界区或子宫内膜也会产生收缩。子宫肌瘤所承受的机械力并不只有这些,由于肌瘤的细胞外基质坚硬,肌瘤还会受到挤压和应变,即长度的百分比变化。这些力会随着肿瘤位置的不同而变化。强烈的子宫收缩不仅会引起疼痛,还可能导致子宫肌瘤生长,进而加重症状。本综述将讨论非妊娠子宫的子宫收缩以及机械力对子宫肌瘤细胞的影响。
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Stressed out: how forces from uterine contractions influence fibroid progression, a Narrative Review
Uterine fibroids are exposed to significant mechanical forces due to routine, monthly uterine contractions and have also been found to generate contractions in the junctional zone or inner myometrium. These are not the only mechanical forces that uterine fibroids experience but also compression and strain, or percent change in length, due to the stiff extracellular matrix of the fibroids. The forces may vary by location within the tumor. Strong uterine contractions not only cause pain but may also contribute to uterine fibroid growth, which, in turn, may lead to worsening symptom severity. This review discusses uterine contractions in the nonpregnant uterus and what is known about the impacts of mechanical forces on uterine fibroid cells.
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来源期刊
F&S reviews
F&S reviews Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Urology
CiteScore
3.70
自引率
0.00%
发文量
0
审稿时长
61 days
期刊最新文献
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